Synthesis of biheteroaryls via 2-methyl quinoline C(sp^(3))-H functionalization under metal-free conditions  

作　　者：Dahan Wang Yuhan Yang Fuhong Xiao Jinbing Liu Guojiang Mao Guo-Jun Deng 

机构地区：[1]Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education,Hunan Province Key Laboratory of Green Organic Synthesis and Application,College of Chemistry,Xiangtan University,Xiangtan 411105,China [2]Department of Food and Chemical Engineering,Shaoyang University,Shaoyang 422100,China [3]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China

出　　处：《Green Synthesis and Catalysis》2024年第1期73-76,共4页绿色合成与催化（英文）

基　　金：Support by the National Natural Science Foundation of China(Nos.22271244,21871226 and 21572194);Postgraduate Scientific Research Innovation Project of Hunan Province(No.CX20200631);the Open Research Fund of the School of Chemistry and Chemical Engineering of Henan Normal University(No.2022C02)is gratefully acknowledged.

摘　　要：An acetic acid-promoted C(sp^(3))-H functionalization of 2-methyl quinoline,enaminoesters and elemental sulfur for the synthesis of 3,4,5-trisubstituted isothiazoles under metal-free conditions has been developed.This approach provides viable access to various 5-(quinolin-2-yl)isothiazoles in moderate to good yields with good functional group tolerance.Moreover,the success of the gram-scale reaction gives this reaction a great potential application.

关 键 词：C(sp^(3))-H functionalization Multicomponent reactions Biheteroaryls Elemental sulfur METAL-FREE 

分 类 号：O62[理学—有机化学]