儿童EB病毒感染相关肝损伤研究进展马子坤综述,赵新颜审校  

Epstein-Barr virus infection-associated liver injury in children

作　　者：马子坤(综述) 赵新颜(审校)[1] Ma Zikun;Zhao Xinyan(Liver Disease Center,National Center for Clinical Medicine of Digestive Diseases,Friendship Hospital Affiliated to Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院肝病中心/国家消化系统疾病临床医学研究中心,北京市100050

出　　处：《实用肝脏病杂志》2024年第2期317-320,共4页Journal of Practical Hepatology

摘　　要：EB病毒是人疱疹病毒家族成员之一,可引起很多疾病。儿童EB病毒感染性疾病多伴有肝损伤,通常表现为轻至中度肝功能异常,重者可发展为肝衰竭,甚至死亡。大多数急性感染患儿经对症支持治疗后恢复正常,而慢性感染或移植术后感染,在积极治疗原发病的同时,需进行免疫调节、化疗和骨髓移植等治疗。本文对儿童EB病毒感染相关肝损伤的流行病学、发病机制、诊疗和预后进行综述,为临床诊治提供参考。The Epstein-Barr virus(EBV)is one of the members of the human herpesvirus family,which might cause many diseases.The children with EBV infection often have liver injury,which is usually manifested as mild to moderate liver dysfunctions.In severe cases,it can develop into liver failure and even lead to death.Most children with acute EB viral infection recover after supportive treatment.However,in cases of chronic infection or post-transplant infection,the immunomodulatory therapy,chemotherapy,and even bone marrow transplantation may be required in addition to actively management of the underlying diseases.In this review,we describes the comprehensive updates of the epidemiology,pathogenesis,diagnosis,treatment and prognosis of children with liver injury associated with EBV infection.

关 键 词：EB病毒感染 肝损伤 儿童 

分 类 号：R725.1[医药卫生—儿科]