儿泻康贴膜治疗小儿腹泻的成本-效果  

Cost-effectiveness Analysis of Erxikang Film in the Treatment of Infantile Diarrhea

作　　者：李璇 蔡秋晗 张依 蔡莉莉 胡思源[1] LI Xuan;CAI Qiu-Han;ZHANG Yi;CAI Li-Li;HU Si-Yuan(Clinical Trial Center,The First Affiliated Hospital of Tianjin University of Chinese Medicine/National Clinical Research Center of TCM Acupuncture and Moxibustion,Tianjin 300381,China)

机构地区：[1]天津中医药大学第一附属医院/国家中医针灸临床医学研究中心、临床试验中心,天津300381

出　　处：《中国药物经济学》2023年第12期11-16,共6页China Journal of Pharmaceutical Economics

摘　　要：目的 探讨儿泻康贴膜治疗小儿寒性腹泻的经济性。方法 基于4家中心开展的儿泻康贴膜治疗小儿腹泻的随机对照试验,共纳入观察组123例,对照组121例。对两组治疗5 d的疾病疗效(愈显率)、单项症状(大便次数、粪便性质、腹痛、食欲不振、肠鸣、发热恶寒、鼻塞流涕、咳嗽咽痒、异常舌质、异常舌苔、异常脉象或指纹)消失情况,从医疗机构角度出发,进行成本-效果分析,并进行敏感性分析。结果 观察组疾病疗效(愈显率)、异常大便次数消失率、异常粪便性质消失率、食欲不振消失率高于对照组,差异有统计学意义(P<0.05)。相比于对照组,观察组每提高1%的疾病疗效(愈显率)、异常大便次数消失率、异常粪便性质消失率、食欲不振消失率,分别需要多花费5.33、5.26、6.74、7.55元。敏感性分析结果与成本-效果分析结果一致。结论 对于改善疾病疗效、异常大便次数、异常粪便性质、食欲不振症状方面,在效果较好的情况下,所增加的成本是值得的,与对照组相比,具有经济学优势。Objective To explore the economics of Erxikang film in treating cold diarrhea in children.Methods Randomized controlled trial of Erxie Kang film in treatment of children with cold diarrhea conducted in 4 centers.A total of 123 cases were included in the treatment group and 121 cases in the control group.From the perspective of medical institutions,cost-effectiveness analysis and sensitivity analysis were conducted for the disease efficacy(rate of recovery)and the disappearance of single symptoms(frequency of stool,nature of stool,abdominal pain,loss of appetite,bowel call,fever and aversion,nasal obstruction and runny nose,cough and throat itching,abnormal tongue quality,abnormal tongue coating,abnormal pulse or fingerprint)in the two groups after 5 days of treatment.Results The curative effect of disease(apparent rate),the disappearance rate of abnormal stool frequency,the disappearance rate of abnormal fecal nature and the disappearance rate of loss of appetite in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Compared with the control group,the observation group needed 5.33,5.26,6.74 and 7.55 yuan more for each 1%increase in the disease effect(more apparent rate),the disappearance rate of abnormal stool frequency,the disappearance rate of abnormal stool nature and the disappearance rate of loss of appetite,respectively.The results of sensitivity analysis were consistent with those of cost-effectiveness analysis.Conclusion For the improvement of disease efficacy,abnormal stool frequency,abnormal stool nature,loss of appetite symptoms,in the case of better results,the increased cost is worthwhile,compared with the control group,has economic advantages.

关 键 词：儿泻康贴膜 成本-效果分析 小儿腹泻 药物经济学评价 

分 类 号：R725.7[医药卫生—儿科] R956[医药卫生—临床医学]