口服泛影葡胺在腹腔镜胃癌根治手术患者快速康复中的应用价值  

Application Value of Oral Meglumine in Rapid Recovery of Patients undergoing Laparoscopic Radical Gastrectomy for Gastric Cancer

作　　者：韦合雷 莫毓[1] 尹林[1] 蔡尚坤[1] 李海寿 黄客增[1] WEI He-Lei;MO Yu;YIN Lin;CAI Shang-Kun;LI Hai-Shou;HUANG Ke-Zeng*(Department of Gastrointestinal Surgery,Hechi People's Hospital,Hechi 547000,China)

机构地区：[1]河池市人民医院胃肠外科,广西河池547000

出　　处：《中国药物经济学》2023年第12期45-48,共4页China Journal of Pharmaceutical Economics

摘　　要：目的 探讨口服泛影葡胺在腹腔镜胃癌根治手术患者快速康复中的应用价值。方法 选取2021年1月至2023年1月河池市人民医院收治的98例腹腔镜胃癌根治术患者作为研究对象,按照随机数字表法分为对照组与观察组,各49例。对照组术后12 h口服0.9%氯化钠注射液,观察组术后12 h口服76%的复方泛影葡胺。比较两组患者临床指标,酶联免疫吸附试验(ELISA)法检测血清炎症因子,采用主诉疼痛程度分级法(VRS)评价疼痛程度,观察两组患者术后并发症发生情况。结果 与对照组相比,观察组患者术后肛门排气时间、肛门排便时间、住院时间均缩短,差异有统计学意义(P<0.05);治疗前,两组患者血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者血清IL-6、IL-8及TNF-α水平均降低(P<0.05),与对照组相比,观察组患者血清IL-6、IL-8及TNF-α水平降低(P<0.05);治疗前,两组患者VRS评分比较差异无统计学意义(P>0.05);治疗后第1天、第3天及第7天,与对照组比较,观察组VRS评分均降低(P<0.05);观察组术后并发症发生率低于对照组(P<0.05)。结论 腹腔镜胃癌根治术后患者口服泛影葡胺可缩短排气排便时间,通过降低炎症因子表达而改善疼痛,同时降低术后并发症发生,加快患者术后康复。Objective To explore the value of oral meglumine in rapid recovery of patients undergoing laparoscopic radical gastrectomy for gastric cancer.Methods Ninety-eight patients with laparoscopic radical gastrectomy treated in Hechi People's Hospital from January 2021 to January 2023 were selected as the study objects,and were divided into control group and observation group according to random number method,with 49 cases in each group.The control group received 0.9%sodium chloride injection orally 12 h after surgery,and the observation group received 76%of recurrent meglumine orally 12 h after surgery.Clinical indicators of the two groups were compared,serum inflammatory factors were detected by enzyme-linked immunosorbent assay(ELISA),pain degree was evaluated by chief complaint pain degree grading(VRS),and postoperative complications in the two groups were observed.Results Compared with the control group,the postoperative anal exhaust time,anal defecation time and hospital stay in the observation group were shortened,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in serum levels of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)between 2 groups(P>0.05).After treatment,serum levels of IL-6,IL-8 and TNF-αin 2 groups were decreased(P<0.05),and serum levels of IL-6,IL-8 and TNF-αin observation group were decreased compared with control group(P<0.05).Before treatment,there was no significant difference in VRS scores between the two groups(P>0.05).On day 1,day 3 and day 7 after treatment,VRS scores in observation group were decreased compared with control group(P<0.05).The incidence of postoperative complications in observation group was lower than that in control group(P<0.05).Conclusion After laparoscopic radical gastrectomy for gastric cancer,oral administration of meglumine can shorten the time of exhaust defecation,improve pain by reducing the expression of inflammatory factors,reduce postoperative complications,and accelerat

关 键 词：胃癌 腹腔镜 泛影葡胺 疼痛 炎症 并发症 

分 类 号：R656.6[医药卫生—外科学] R982[医药卫生—临床医学]