高龄妊娠对孕产妇心理及子代神经行为发育的影响及相关机制研究进展  

Research progress on the effect of advanced maternal age on maternal psychology and neurobehavioral development of their offspring and related mechanisms

作　　者：刘芳[1] 李梦诗 田甜 傅郁 王晓莉[2] 王媛媛[1] 乔杰[1] Liu Fang;Li Mengshi;Tian Tian;Fu Yu;Wang Xiaoli;Wang Yuanyuan;Qiao Jie(Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital/National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital)/Key Laboratory of Assisted Reproduction(Peking University),Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology,Beijing 100191,China;Department of Maternal and Child Health,School of Public Health,Peking University,Beijing 100191,China)

机构地区：[1]北京大学第三医院妇产科生殖医学中心,国家妇产疾病临床医学研究中心(北京大学第三医院),辅助生殖教育部重点实验室(北京大学),北京市生殖内分泌与辅助生殖技术重点实验室,北京100191 [2]北京大学公共卫生学院妇幼卫生学系,北京100191

出　　处：《中华生殖与避孕杂志》2024年第1期77-82,共6页Chinese Journal of Reproduction and Contraception

基　　金：北京市科学技术委员会(Z191100006619073);国家自然科学基金(82204052);国家重点研发计划(2022YFC2705305)。

摘　　要：随着生活方式、婚育观念及生育政策的变化,我国高龄孕妇比例快速攀升。高龄妊娠和高龄所致的母体压力状态是孕妇心理健康及其子代神经行为发育的独立危险因素。本文系统阐述了胶质细胞源性神经营养因子、下丘脑-垂体-肾上腺轴、5-羟色胺系统、催产素等影响高龄孕产妇心理及子代神经行为发育的作用机制及潜在干预手段,目前的干预手段主要包括人工补充剂、抗抑郁药物、体育锻炼、营养素补充等,但疗效有限且部分治疗措施有较高的不良反应发生风险,目前尚缺乏具有针对性的、系统的干预措施。未来研究中应进一步深入探究相关发病机制并提出更加安全有效的干预措施,保障高龄孕产妇心理健康及其子代的长期健康发展。With the changes in lifestyle,marriages and childbearing concepts,and population policies in recent years,the proportion of women with advanced maternal age(AMA)in China is rising rapidly.AMA and maternal stress due to advanced age are considered as independent risk factors for maternal mental health and the neurobehavioral development of their offspring.In this paper,we summarized how the glial cell line-derived neurotrophic factor,the hypothalamic-pituitary-adrenal axis,the 5-HT system and the oxytocin affect the maternal mental health and the neurobehavioral development of their offspring,as well as some potential targeted interventions.Interventions currently being developed include artificial supplements,antidepressants,physical exercise,nutrient supplementation,etc.,but they have a limited efficacy and a high risk of side effects,yet there is still a lack of specific and systematic interventions.The relevant pathogenesis should continue to be explored in the future research,and hopefully more effective and safe interventions will be given in the near future to improve the mental health of mothers with AMA and the long-term healthy development of their offspring.

关 键 词：母亲年龄 孕产妇健康 发育障碍 神经行为学表现 胶质细胞源性神经营养因子 血清素 催产素 下丘脑-垂体-肾上腺轴 

分 类 号：R714[医药卫生—妇产科学]