肺源分配评分与特发性肺纤维化患者肺移植术后早期死亡风险的相关性分析  

Correlation between lung allocation score and early death risk of patients with idiopathic pulmonary fibrosis after lung transplantation

作　　者：顾美蓉 刘民强[2] 戴韬寅 顾思佳 李小杉 许波 胡春晓 陈静瑜 Gu Meirong;Liu Minqiang;Dai Taoyin;Gu Sijia;Li Xiaoshan;Xu Bo;Hu Chunxiao;Chen Jingyu(Wuxi Medical Center,Nanjing Medical University,Wuxi People's Hospital,Department of Anesthesiology,the Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi 214023,China;不详)

机构地区：[1]南京医科大学无锡医学中心、无锡市人民医院南京医科大学附属无锡人民医院麻醉科,江苏无锡214023 [2]深圳市第三人民医院麻醉科 [3]南京医科大学附属无锡人民医院肺移植中心

出　　处：《器官移植》2024年第2期251-256,共6页Organ Transplantation

基　　金：江苏省科技计划重点研发项目(BE2022697);南京医科大学无锡医学中心专病队列和临床研究项目(WMCC202301);无锡市太湖人才计划国际国内顶尖医学专家团队(2019-THRCTD-1)。

摘　　要：目的 分析肺源分配评分(LAS)与特发性肺纤维化(IPF)患者肺移植术后早期死亡风险及并发症的相关性。方法 回顾性分析275例IPF患者临床资料,采用单因素和多因素Cox回归分析LAS与IPF患者肺移植术后早期死亡风险的相关性,以及LAS与术后1年并发症发生的相关性。结果 275例受者中,术后30、90、180、365 d内分别死亡62例、83例、95例和108例。LAS与IPF患者肺移植术后30、90、180、365 d死亡风险相关(均为P<0.05),但与术后365 d原发性移植物功能障碍(PGD)、急性肾损伤(AKI)发生无关(均为P>0.05)。结论 LAS与IPF患者肺移植术后早期死亡相关,LAS与术后早期PGD、AKI的发生无关,但应关注综合因素对PGD、AKI发生的影响。Objective To analyze the correlation between the lung allocation score(LAS) and the risk of early death and complications in patients with idiopathic pulmonary fibrosis(IPF) after lung transplantation.Methods Clinical data of 275 patients with IPF were retrospectively analyzed.The correlation between LAS and the risk of early death in IPF patients after lung transplantation and the correlation between LAS and complications at postoperative 1 year was assessed by univariate and multivariate Cox regression analyses.Results Among 275 recipients,62,83,95 and 108 cases died within postoperative 30,90,180 and 365 d,respectively.LAS was correlated with 30-,90-,180-and 365-d fatality of IPF patients(all P<0.05),whereas it was not correlated with the incidence of primary graft dysfunction(PGD) and acute kidney injury(AKI) at 365 d after lung transplantation(both P>0.05).Conclusions LAS is correlated with the risk of early death of IPF patients after lung transplantation.While,it is not correlated the incidence of PGD and AKI early after lung transplantation.Special attention should be paid to the effect of comprehensive factors upon PGD and AKI.

关 键 词：肺移植 肺源分配评分 特发性肺纤维化 原发性移植物功能障碍 急性肾损伤 氧合指数 胆红素 中心静脉压 

分 类 号：R617[医药卫生—外科学] R563[医药卫生—临床医学]