CD47在肾移植中的最新研究与展望  

Latest research and prospect of CD47 in kidney transplantation

作　　者：陈羽翔 李卓骋 高亮 朱许源 张宇 李涛 蒋鸿涛 Chen Yuxiang;Li Zhuocheng;Gao Liang;Zhu Xuyuan;Zhang Yu;Li Tao;Jiang Hongtao(Department of Transplantation,the Second Affiliated Hospital of Hainan Medical University,Haikou 570100,China)

机构地区：[1]海南医学院第二附属医院移植科,海口570100

出　　处：《器官移植》2024年第2期282-288,共7页Organ Transplantation

基　　金：海南省自然科学基金(820RC766、821QN413);海南省临床医学中心建设项目;海南省研究生创新科研课题(Qhys2022-227);海南医学院研究生创新科研课题(HYYB2022A07)。

摘　　要：CD47是一种广泛表达于细胞表面的跨膜蛋白,被认为是细胞发生免疫逃逸的关键分子。随着相关研究日益增多,CD47及其配体参与的免疫调节作用逐渐被人们所知晓。近年来,多项研究探讨了CD47在同种异体肾移植缺血-再灌注损伤、排斥反应以及异种肾移植中的作用,但具体作用还有待明确,关键机制仍不清楚。因此,本文从CD47的结构和功能、CD47的常见配体、CD47与肾移植的关系以及CD47在肾移植中的应用进行综述,总结CD47在肾移植中的最新研究进展,分析现有研究的不足和未来研究的方向,以期为后续CD47在同种和异种肾移植中的应用提供参考。CD47 is a transmembrane protein widely expressed on cell surface,which is considered as a key molecule for immune escape.With an increasing number of related studies,the role of CD47 and its ligands in immunomodulatory effects has been gradually understood.Recent studies have investigated the role of CD47 in ischemiareperfusion injury of allogenetic kidney transplantation,rejection and xenotransplantation.Nevertheless,the specific role and the key mechanism remain elusive.In this article,the structure and function of CD47,common CD47 ligands,the relationship between CD47 and kidney transplantation,and the application of CD47 in kidney transplantation were reviewed,the latest research progress of CD47 in kidney transplantation was summarized,and the limitations of current research and subsequent research direction were analyzed,aiming to provide reference for subsequent application of CD47in allogeneic and kidney xenotransplantation.

关 键 词：CD47 肾移植 异种移植 排斥反应 缺血-再灌注损伤 免疫细胞 信号调节蛋白 血小板反应蛋白 

分 类 号：R617[医药卫生—外科学] R392[医药卫生—临床医学]