基于中西医病证特点的腹泻型肠易激综合征动物模型的临床吻合度分析  

Fitting Degrees of Animal Models of Diarrhea-irritable Bowel Syndrome with Clinical Characteristics of Western Medicine and Traditional Chinese Medicine

作　　者：蒋风茹 何友成 吴月 潘可怡 周淳宇 蔡舒雨 袁建业[1] JIANG Fengru;HE Youcheng;WU Yue;PAN Keyi;ZHOU Chunyu;CAI Shuyu;YUAN Jianye(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《中国实验方剂学杂志》2024年第6期218-227,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：上海市名中医谢建群工作室建设项目;上海市“科技创新行动计划”医学创新研究专项(21Y11922600);国家自然科学基金项目(81874391)。

摘　　要：腹泻型肠易激综合征(IBS-D)是临床常见的功能性肠病之一,其发病机制复杂且未被完全阐明,现代医学缺乏稳定且行之有效的治疗方式。建立符合中西医病证特点的IBS-D动物模型有助于进一步揭示其发病机制并完善治疗方案。临床吻合度是一种以疾病中西医最新诊断标准为依据,评价动物模型对中西医病证模拟效果的指标。该文通过对IBS-D动物模型相关文献进行分析归纳,发现IBS-D模型所用动物多以大鼠为主,所用方法多为单因素诱导、双因素诱导和多因素联合诱导,所表现的疾病特征主要是与内脏痛觉过敏或(和)胃肠动力异常相关的症状和(或)体征。其中,单因素诱导IBS-D大鼠模型多具备很高的西医临床吻合度,而中医临床吻合度不足;双因素诱导和多因素诱导的IBS-D模型西医临床吻合度多数较高,但也存在吻合度水平参差不齐的情况。此外,IBS-D中医证候模型构建以肝郁脾虚证为主,而脾肾阳虚、脾胃湿热、脾虚湿盛,寒热错杂证候模型略显不足。因此,今后仍需进一步完善已有的或研发新的IBS-D动物模型,为本病的中西医病证机制探索和治疗手段研发提供更适用的工具。Diarrhea-irritable bowel syndrome(IBS-D)is one of the common functional bowel diseases in clinical practice.Since it pathogenesis is complex and has not been fully elucidated,effective treatment methods remains to be developed for this disease.Establishing the animal models of IBS-D in accordance with the clinical characteristics of traditional Chinese medicine(TCM)and Western medicine helps to reveal the pathogenesis of this disease and improve the treatment plan.The fitting degree of an animal model with clinical characteristics is an indicator to evaluate the effectiveness of the animal model in simulating the disease characteristics of Western medicine and the syndromes of TCM based on the latest diagnostic standards.By reviewing the relevant articles about the animal models of IBS-D,we discovered that rats were the preferred animals for modeling,and the models were mainly induced by single factors,double factors,or the combination of multiple factors.The established animal models mainly present symptoms or signs associated with visceral hypersensitivity or/and gastrointestinal motility abnormalities.The single factor-induced rat models of IBS-D had high fitting degrees with the clinical characteristics of Western medicine but low fitting degrees with the TCM syndromes.The animal models induced by two or more factors had high but varied fitting degrees with the clinical characteristics of Western medicine.In addition,the animal models of IBS-D considering TCM syndromes mainly focuses on the syndrome of liver depression and spleen deficiency,and few models were established for the syndromes of spleen-kidney Yang deficiency,spleen-stomach dampness-heat,spleen deficiency and dampness excess,and cold and heat in complexity.Therefore,it is essential to improve the existing or develop new animal models of IBS-D in the future,so as to provide more tools for deciphering the mechanisms of TCM and Western medicine and developing treatment methods for this disease.

关 键 词：腹泻型肠易激综合征 动物模型 中西医病证特点 临床吻合度 

分 类 号：R2-0[医药卫生—中医学] R242R2-031R259R574R965