中药干预细胞焦亡防治骨关节相关疾病机制研究进展  

Mechanism of Traditional Chinese Medicine Intervening in Pyroptosis to Prevent and Treat Bone and Joint Related Diseases:A Review

作　　者：柴居堂 宁红霞 李永章 刘小钰[3] 魏晓涛 刘涛 温志刚[1] CHAI Jutang;NING Hongxia;LI Yongzhang;LIU Xiaoyu;Wei Xiaotao;LIU Tao;WEN Zhigang(Hebei Provincial Hospital of Chinese Medicine,Shijiazhuang 050000,China;Shijiazhuang Hospital of Traditional Chinese Medicine(TCM),Shijiazhuang 050000,China;Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of TCM,Lanzhou 730000,China)

机构地区：[1]河北省中医院,石家庄050000 [2]石家庄市中医院,石家庄050000 [3]甘肃中医药大学,兰州730000 [4]甘肃省中医院,兰州730000

出　　处：《中国实验方剂学杂志》2024年第6期289-298,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81860863,81660802);河北省中医药管理局科研计划项目(2021044)。

摘　　要：骨关节炎(OA)、类风湿关节炎(RA)、痛风性关节炎(GA)、椎间盘退变(IVDD)作为临床上最为常见的几种骨关节相关疾病,均可累及相关关节,导致关节疼痛、肿胀、功能障碍等症状,不同的是OA主要是由于关节磨损和年龄相关的退化导致的,表现为关节疼痛、僵硬和运动受限,RA是一种自身免疫性疾病,表现为关节疼痛、肿胀、晨僵和全身症状,GA是尿酸代谢异常引起的关节炎,表现为急性关节炎,而IVDD是椎间盘结构退行性变引起的。研究表明,上述骨关节疾病发生发展机制极其复杂,细胞焦亡通过参与骨关节炎症反应、软骨代谢失衡、细胞外基质降解、骨关节病理损伤与上述骨关节相关疾病密切相关,抑制骨关节相关细胞细胞焦亡将有效防治骨关节相关疾病。同时众多研究证实,中医药防治骨关节相关疾病疗效突出、优势明显,中医药能够通过抑制细胞焦亡,达到减轻骨关节炎症反应、改善骨关节疾病病理损伤、缓解骨关节疼痛的治疗作用。因此,该文以期通过阐述细胞焦亡与骨关节相关疾病发生发展的关系,并总结中药单体、中药提取物及中药复方干预细胞焦亡治疗骨关节相关疾病的最新研究报道,为骨关节疾病发病机制及药物治疗的深入研究提供新思路,为临床上运用中医药防治骨关节疾病提供依据。Osteoarthritis(OA),rheumatoid arthritis(RA),gouty arthritis(GA),and intervertebral disc degeneration(IVDD)are the most common bone and joint-related diseases in clinical practice.They can all affect related joints,leading to joint pain,swelling,dysfunction,and other symptoms.The difference is that OA is mainly caused by joint wear and age-related degradation and is manifested as joint pain,stiffness,and limited movement.RA is an autoimmune disease,manifested as joint pain,swelling,morning stiffness,and systemic symptoms.GA is caused by abnormal uric acid metabolism,manifested as acute arthritis,and IVDD is caused by intervertebral disc degeneration.Studies have shown that the mechanism of the occurrence and development of these bone and joint diseases is extremely complex.Pyroptosis is closely related to these bone and joint-related diseases by participating in bone and joint inflammation,cartilage metabolism imbalance,extracellular matrix degradation,and pathological damage of bone and joint.Inhibition of bone and joint-related pyroptosis will effectively prevent and treat bone and joint-related diseases.At the same time,many studies have confirmed that traditional Chinese medicine(TCM)has a prominent curative effect and obvious advantages in the prevention and treatment of bone and joint-related diseases.TCM can reduce the inflammatory reaction of bone and joints,improve the pathological damage of bone and joint diseases,and relieve bone and joint pain by inhibiting pyroptosis.Therefore,this article aims to briefly explain the relationship between pyroptosis and the occurrence and development of bone and joint-related diseases and summarize the latest research reports on the intervention of pyroptosis in the treatment of bone and joint-related diseases by TCM monomers,TCM extracts,and TCM compounds.It offers new ideas for the in-depth study of the pathogenesis and drug treatment of bone and joint diseases and provides a basis for the clinical use of TCM to prevent and treat bone and joint diseases.

关 键 词：细胞焦亡 骨关节炎 类风湿关节炎 痛风性关节炎 椎间盘退变 中医药 

分 类 号：R2-0[医药卫生—中医学] R22R242R287R274