乌药提取物及有效成分抗肝损伤的药理作用研究进展  

Research progress on anti-hepatic injury effects of extracts of Lindera aggregataand its active components

作　　者：欧阳婷 刘涛 欧阳林旗[1,3] OUYANG Ting;LIU Tao;OUYANG Linqi(The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China;The First Hospital of Changsha,Changsha 410005,China;College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]长沙市第一医院,湖南长沙410005 [3]湖南中医药大学药学院,湖南长沙410208

出　　处：《药物评价研究》2024年第1期197-203,共7页Drug Evaluation Research

基　　金：湖南省自然科学基金资助项目(2020JJ5434);湖南省卫生健康委科研项目(C202313057956,D202302048806);湖南中医药大学校级科研基金(2019XJJJ033,2021XJJJ040,2022XYLH004);湖南省“十四五”中医重点专科:中药学资助项目(湘中医药函[2023]4号)。

摘　　要：乌药为樟科山胡椒属植物乌药Lindera aggregata (Sims) Kosterm.的干燥块根,主要成分包括倍半萜类、生物碱类、黄酮类和挥发油等,具有抗氧化、抑菌、抗炎镇痛、抗肿瘤等多种药理作用。近年,诸多研究表明乌药对酒精性肝损伤、化学性肝损伤、免疫性肝损伤、糖尿病合并肝损伤、脂肪肝、肝癌等肝脏相关疾病都有防治作用。综述了乌药水提取物、醇提取物、醇提取物的萃取物、叶提取物、根挥发油及乌药醚内酯抗肝损伤的药理作用及研究现状,以期为后续乌药相关保肝药物的开发及利用提供理论基础。Lindera aggregata was the dried root tubers of Lindera aggregata(Sims)Kosterm.The main components include sesquiterpenoids,alkaloids,flavonoids and volatile oils,which have various pharmacological effects such as antioxidant,antibacterial,anti-inflammatory and analgesic,and anti-tumour.In recent years,many studies have shown that Lindera aggregata has been effective against alcoholic liver injury,chemical liver injury,immune liver injury,diabetes combined with liver injury,fatty liver,liver cancer and other liver-related diseases.This article reviewed the pharmacological effects on liver injury and research status of water extract,alcohol extract,various extracts of alcohol extract,leaf extract,volatile oil of Lindera aggregata and linderane,providing a theoretical basis for the subsequent development and utilization of Lindera aggregata related drugs.

关 键 词：乌药 乌药醚内酯 肝损伤 脂肪肝 肝癌 作用机制 

分 类 号：R285.5[医药卫生—中药学]