阿托品在不明原因反复胚胎种植失败患者中的应用效果及对子宫收缩的影响研究  

Effects of Atropine on Uterine Contraction in Patients with Unexplained Repeated Embryo Implantation Failure

作　　者：任文超[1] 任春娥[1] 丁成成 张兴丽 张茂翔[1] REN Wenchao;REN Chun'e;DING Chengcheng;ZHANG Xingli;ZHANG Maoxiang(Department of Reproductive Center,the Affiliated Hospital of Weifang Medical College,Weifang,Shandong Province,261031 China)

机构地区：[1]潍坊医学院附属医院生殖中心,山东潍坊261031

出　　处：《中外医疗》2023年第36期25-28,共4页China & Foreign Medical Treatment

基　　金：山东省医药卫生科技发展计划项目(202005030464)。

摘　　要：目的 探讨阿托品在不明原因反复胚胎种植失败患者中的应用效果及对子宫收缩的影响。方法 方便选取2021年1月—2022年10月潍坊医学院附属医院收治的165例不明原因反复胚胎种植失败患者为研究对象,根据治疗药物的不同分为研究组和对照组,研究组84例在移植日肌肉注射硫酸阿托品注射液,而对照组81例则不进行阿托品注射,比较两组的应用效果。结果 研究组的临床妊娠率为41.46%,胚胎着床率为33.90%,高于对照组的28.40%、19.82%,差异有统计学意义(χ^(2)=5.349、6.478,P均<0.05);两组早期流产率与异位妊娠率比较,差异无统计学意义(P均>0.05);治疗前,两组子宫收缩幅度比较,差异无统计学意义(P>0.05),治疗后,研究组的子宫收缩频率低于对照组,差异有统计学意义(P<0.05);两组子宫内膜血流参数比较,差异无统计学意义(P>0.05)。结论 阿托品可以提高不明原因反复胚胎种植失败患者的临床妊娠率以及胚胎着床率,同时对于子宫收缩频率有一定程度的降低,对临床具有一定的指导意义。Objective To investigate the effect of atropine on uterine contraction in patients with unexplained repeated embryo implantation failure.Methods 165 patients with unexplained repeated embryo implantation failure admitted to the Affiliated Hospital of Weifang Medical College from January 2021 to October 2022 were conveniently selected.They were divided into study group and control group according to the different therapeutic agents.84 patients in the study group received intramuscular injection of atropine sulfate on the transplantation day,while 81 patients in the control group did not receive atropine injection.The application effect of the two groups were compared.Results The clinical pregnancy rate of 41.46% and implantation rate of 33.90% in the study group,which were higher than 28.40%and 19.82% in the control group,and the differences were statistically significant(χ^(2)=5.349,6.478,both P<0.05).There was no statistically significant difference in the early abortion rate and ectopic pregnancy rate between the two groups(both P>0.05).Before treatment,there was was no statistically significant difference in the amplitude of uterine contraction between the two groups(P>0.05).After treatment,the frequency of uterine contractions in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in endometrial blood flow parameters between the two groups(P>0.05).Conclusion Atropine can improve the clinical pregnancy rate and embryo implantation rate of patients with unexplained repeated embryo implantation failure,and reduce the frequency of uterine contraction to a certain extent,which has certain clinical guiding significance.

关 键 词：阿托品 子宫收缩 反复胚胎种植失败 应用效果 

分 类 号：R4[医药卫生—临床医学]