孕早期FBG、HbA1c、TC、TG联合检测在妊娠期糖尿病诊断中的应用价值研究  

Application Value of Combined Detection of FBG,HbA1c,TC and TG in Early Pregnancy in the Diagnosis of Gestational Diabetes Mellitus

作　　者：张杰民 黄诗勇 陈玲玲 ZHANG Jiemin;HUANG Shiyong;CHEN Lingling(Department of Clinical Laboratory,Quanzhou Fengze District Maternal and Child Health Hospital,Quanzhou,Fujian Province,362000 China)

机构地区：[1]泉州市丰泽区妇幼保健院检验科,福建泉州362000

出　　处：《糖尿病新世界》2023年第24期45-48,共4页Diabetes New World Magazine

摘　　要：目的对孕早期孕妇采用空腹血糖(fasting blood glucose,FBG)、糖化血红蛋白(glycosylated hemoglo-bin,HbA1c)、血清总胆固醇(serum total cholesterol,TC)、三酰甘油(triglyceride,TG)联合检测在妊娠期糖尿病(gestational diabetes mellitus,GDM)诊断中的临床应用价值。方法选取2020年1月—2022年12月于泉州市丰泽区妇幼保健院就诊的56例妊娠期糖尿病患者为观察组,同时选取本院同期56例健康孕妇为对照组。两组孕妇均在孕12周内进行FBG、HbA1c、TC、TG检测,对比两组孕妇FBG、HbA1c、TC、TG联合诊断妊娠期糖尿病的结果。结果观察组FBG(6.36±1.14)mmol/L高于对照组(4.13±0.52)mmol/L,差异有统计学意义(P<0.05);观察组HbA1c(7.54±1.48)%高于对照组(5.35±0.86)%,差异有统计学意义(P<0.05);观察组TC(5.74±1.15)mmol/L高于对照组(5.15±0.98)mmol/L,差异有统计学意义(P<0.05);观察组TG(1.95±0.84)mmol/L高于对照组(1.60±0.67)mmol/L,差异有统计学意义(P<0.05)。FBG、HbA1c、TC、TG联合诊断的灵敏度、特异度和准确度均高于FBG单独诊断的灵敏度、特异度和准确度,差异有统计学意义(P均<0.05)。结论在孕早期采用FBG、HbA1c、TC、TG联合诊断妊娠期糖尿病,具有较好的灵敏度、特异度和准确度,可为孕早期妊娠期糖尿病的诊断提供依据。Objective To analyze the clinical value of fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),serum total cholesterol(TC)and triglyceride(TG)in the diagnosis of gestational diabetes mellitus(GDM)in early preg-nancy.Methods 56 patients with gestational diabetes in Quanzhou Fengze District Maternal and Child Health Hospi-tal from January 2020 to December 2022 were selected as the observation group,and 56 healthy pregnant women in the same period of the hospital were selected as the control group.FBG,HbA1c,TC and TG were detected in both groups within 12 weeks of pregnancy,and the results of FBG,HbA1c,TC and TG combined diagnosis of gestational diabetes between the two groups were compared.Results The FBG of observation group(6.36±1.14)mmol/L was higher than that of control group(4.13±0.52)mmol/L,and the difference was statistically significant(P<0.05).HbA1c(7.54±1.48)%in the observation group was higher than that in the control group(5.35±0.86)%,and the difference was statistically significant(P<0.05).The TC(5.74±1.15)mmol/L in observation group was higher than that in control group(5.15±0.98)mmol/L,and the difference was statistically significant(P<0.05).The TG of observation group(1.95±0.84)mmol/L was higher than that of control group(1.60±0.67)mmol/L,and the difference was statistically sig-nificant(P<0.05).The sensitivity,specificity and accuracy of FBG,HbA1c,TC and TG combined diagnosis were all higher than that of FBG alone diagnosis,and the differences were statistically significant(all P<0.05).Conclusion The combination of FBG,HbA1c,TC and TG in the diagnosis of gestational diabetes in the first trimester has good sensitivity,specificity and accuracy,and can provide reference for the diagnosis of gestational diabetes in the first tri-mester.

关 键 词：妊娠期糖尿病 孕早期 空腹血糖 糖化血红蛋白 血清总胆固醇 三酰甘油 联合检测 诊断价值 

分 类 号：R59[医药卫生—内科学]