不同剂量胰岛素对小儿糖尿病酮症酸中毒的疗效比较分析  

Comparative Analysis of Therapeutic Effect of Different Doses of Insulin in Children with Diabetic Ketoacidosis

作　　者：张莉莉 赖素贤[1] 洪顺治 ZHANG Lili;LAI Suxian;HONG Shunzhi(Department of Pediatrics,Quanzhou First Hospital,Quanzhou,Fujian Province,362000 China)

机构地区：[1]泉州市第一医院儿科,福建泉州362000

出　　处：《糖尿病新世界》2023年第24期159-162,共4页Diabetes New World Magazine

摘　　要：目的对比不同剂量胰岛素对小儿糖尿病酮症酸中毒的疗效。方法选取2022年1月—2023年4月泉州市第一医院收治的60例糖尿病酮症酸中毒患儿为研究对象,根据随机数表法分为对照组与观察组。观察组30例患儿接受小剂量胰岛素[0.05 U/(kg·h)]治疗,对照组30例患儿接受常规剂量胰岛素[0.1 U/(kg·h)]治疗。比较两组治疗前后血糖相关指标、尿酮转阴时间、血酮转阴时间、住院时间、低血糖发生率。结果治疗前两组血糖、血钠、血钾水平比较,差异无统计学意义(P>0.05)。治疗后两组血糖、血钠、血钾水平均优于治疗前,差异有统计学意义(P均<0.05);但治疗后两组血糖、血钠、血钾水平比较,差异无统计学意义(P>0.05)。两组尿酮转阴时间、血酮转阴时间、住院时间比较,差异无统计学意义(P>0.05)。观察组低血糖发生率低于对照组,差异有统计学意义(P<0.05)。治疗后两组炎性因子水平均优于治疗前,差异有统计学意义(P<0.05);但治疗后两组炎性因子水平比较,差异无统计学意义(P>0.05)。结论小剂量胰岛素不仅不会影响糖尿病酮症酸中毒患儿的治疗效果,同时也可以预防低血糖发生。Objective To compare the effect of different doses of insulin on children with diabetic ketoacidosis.Methods A total of 60 children with diabetic ketoacidosis treated in Quanzhou First Hospital from January 2022 to April 2023 were selected as the study objects and divided into control group and observation group according to ran-dom number table method.Thirty children in the observation group received low dose of insulin[0.05 U/(kg·h)],and 30 children in the control group received conventional dose of insulin[0.1 U/(kg·h)].Blood glucose related indexes,urine ketone negative conversion time,blood ketone negative conversion time,hospital stay and incidence of hypogly-cemia were compared between the two groups before and after treatment.Results There was no statistically significant difference in blood glucose,sodium and potassium levels between the two groups before treatment(P>0.05).After treatment,the levels of blood glucose,blood sodium and blood potassium in the two groups were better than before treatment,and the differences were statistically significant(all P<0.05);however,there was no statistically significant difference in blood glucose,sodium and potassium levels between the two groups after treatment(P>0.05).There was no statistically significant difference in urine ketone negative time,blood ketone negative time and hospital stay be-tween the two groups(P>0.05).The incidence of hypoglycemia in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).The levels of inflammatory factors after treatment were better than before treatment,and the difference was statistically significant(P<0.05);there was no statistically signifi-cant difference in the levels of inflammatory factors between the two groups after treatment(P>0.05).Conclusion Small dose of insulin not only does not affect the therapeutic effect of children with diabetic ketoacidosis,but also can prevent hypoglycemia.

关 键 词：胰岛素 用药剂量 小儿糖尿病酮症酸中毒 临床疗效 

分 类 号：R587.1[医药卫生—内分泌]