mRNA技术在疫苗领域的探索与实践  

Exploration and practice of mRNA technology in vaccine development

作　　者：刘健 LIU Jian(CanSino Biologics(Shanghai)Co.,Ltd.,Shanghai 201306,China)

机构地区：[1]康希诺生物(上海)有限公司,上海201306

出　　处：《中国药科大学学报》2024年第1期127-136,共10页Journal of China Pharmaceutical University

摘　　要：mRNA疫苗是将编码抗原的mRNA递送到人体细胞内,在细胞内翻译后产生相应的抗原蛋白,从而诱导机体产生有效的免疫反应。与传统疫苗相比,mRNA疫苗安全性好、研发周期短、免疫效力高,可以同时刺激细胞免疫反应和体液免疫反应。随着核苷酸修饰技术和递送技术的发展,mRNA疫苗也迎来了广阔的应用前景。本文对mRNA技术及其在疫苗领域的应用进行综述,以期为正在或即将开展mRNA疫苗研发工作的学者提供理论和实践指导。mRNA vaccine delivers antigen-encoding mRNA into human cells,which translates into corresponding antigen proteins in cells,and induce effective immune responses.Compared with traditional vaccines,mRNA vaccines have good safety profile,short development cycle,and high immune efficacy,and can stimulate both cellular immune response and humoral immune response.With the development of nucleotide modification technology and delivery technology,mRNA vaccines also have broad application prospects.This paper reviews mRNA technology and its application in vaccines,in the hope of offering theoretical and practical insights to researchers engaged or to be engaged in the development of mRNA vaccines.

关 键 词：疫苗 信使核糖核酸 修饰核苷 核酸递送 脂质纳米颗粒 

分 类 号：R186[医药卫生—流行病学] Q522[医药卫生—公共卫生与预防医学]