D-type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light-driven ROS generation ability for NIR-Ⅱ fluorescence imaging-guided through-skull photodynamic therapy of gliomas  

作　　者：Xuelu He Yuan Luo Yanying Li Yuanbo Pan Ryan T.K.Kwok Lulu He Xiaolin Duan Pengfei Zhang Aiguo Wu Ben Zhong Tang Juan Li 

机构地区：[1]Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology,Zhejiang International Cooperation Base of Biomedical Materials Technology and Application,Chinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and Devices,Ningbo Cixi Institute of Biomedical Engineering,Zhejiang Engineering Research Center for Biomedical Materials,Ningbo Institute of Materials Technology and Engineering,Chinese Academy of Sciences,Ningbo,P.R.China [2]Guangdong Key Laboratory of Nanomedicine,Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations,CAS-HK Joint Lab for Biomaterials,Research Laboratory for Biomedical Optics and Molecular Imaging,Shenzhen Key Laboratory for Molecular Imaging,CAS Key Lab for Health Informatics,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,P.R.China [3]Department of Chemistry,Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study,The Hong Kong University of Science and Technology(HKUST),Kowloon,P.R.China [4]School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen,P.R.China

出　　处：《Aggregate》2024年第1期185-195,共11页聚集体（英文）

基　　金：Natural Science Foundation of China,Grant/Award Numbers:T2222021,32011530115,32025021;National Key R&D Programs,Grant/Award Number:2019YFE0198700;Science and Technology Bureau of Ningbo City,Grant/Award Numbers:2020Z094,2021Z072;Excellent Member of Youth Innovation Promotion Association Foundation of CAS,Grant/Award Number:Y2021079;Innovation and Technology Commission,Grant/Award Number:MHP/047/19。

摘　　要：Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in human.Aggregation-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)laser.Unfortunately,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor treatment.In this work,we developed a multifunctional NIR-driven theranostic agent through hybrid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion luminescence.The theranostic agent was further decorated with D-type neuropeptide DNPY for crossing BBB and targeting glioma.Under the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in situ.These results demonstrate that the integration of Dtype neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-skull PDT treatments of brain tumors.

关 键 词：aggregation-induced emission D-type neuropeptide glioma photodynamic therapy rare-earth doping nanoparticles 

分 类 号：O657.3[理学—分析化学]