重组B亚单位/灭活菌体霍乱疫苗预防肠产毒性大肠埃希菌感染性腹泻专家共识  

Expert consensus on recombinant B subunit/inactivated whole-cell cholera vaccine in preventing infectious diarrhea of enterotoxigenic Escherichia coli

作　　者：季钗[1] 胡昱[2] 李明燕[1] 刘艳[3] 许玉洋 俞骅[4] 沈建勇[5] 楼金玕[6] 周伟[7] 胡洁[8] 尹志英[9] 魏晶娇[10] 林君芬[11] 沈振宇[12] 缪梓萍[13] 李保东 吴家兵[15] 李孝远[16] 许红梅[17] 欧剑鸣[18] 李琦[19] 向俊 董琛 易海华 鲍倡俊[23] 郭世 成闫绍宏 刘莉莉[26] 寇增强[27] 常少英[28] 张少白[29] 郭翔[30] 祝小平[31] 张颖[32] 王邦茂[33] 曹曙光[34] 王培生[35] 赵智娴[36] 王达 陈恩富[13] Ji Chai;Hu Yu;Li Mingyan;Liu Yan;Xu Yuyang;Yu Hua;Shen Jianyong;Lou Jingan;Zhou Wei;Hu Jie;Yin Zhiying;Wei Jingjiao;Lin Junfen;Shen Zhenyu;Miao Ziping;Li Baodong;Wu Jiabing;Li Xiaoyuan;Xu Hongmei;Ou Jianming;Li Qi;Xiang Jun;Dong Chen;Yi Haihua;Bao Changjun;Guo Shicheng;Yan Shaohong;Liu Lili;Kou Zengqiang;Chang Shaoying;Zhang Shaobai;Guo Xiang;Zhu Xiaoping;Zhang Ying;Wang Bangmao;Cao Shuguang;Wang Peisheng;Zhao Zhixian;Wang Da;Chen Enfu(Department of Children Health Care,The Children’s Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou 310005,China;Department of Expanded Immunization Program,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310057,China;Department of Immunization Planning,Hangzhou Center for Disease Control and Prevention,Hangzhou 310021,China;Department of Microbiology Laboratory,Hangzhou Municipal Center for Disease Control and Prevention,Hangzhou 310021,China;Huzhou Municipal Center for Disease Prevention and Control,Huzhou 313099,Zhejiang Province,China;Department of Gastroenterology,The Children's Hospital,Zhejiang University School of Medicine,Hangzhou 310005,China;Center for Inflammatory Bowel Disease,Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine,Hangzhou 310020,China;Jiaxing Municipal Center for Disease Prevention and Control,Jiaxing 314050,Zhejiang Province,China;Quzhou Center for Disease Prevention and Control,Quzhou 324003,Zhejiang Province,China;Wenzhou Municipal Center for Disease Control and Prevention,Wenzhou 325000,Zhejiang Province,China;Department of Disease Surveillance,Zhejiang Provincial Centre for Disease Control and Prevention,Hangzhou 310057,China;Department of Pediatrics,The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510062,China;Department of Infectious Diseases Control,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310057,China;Department of Gastrointestinal Surgical Oncology,Zhengzhou University Affiliated Cancer Hos

机构地区：[1]浙江大学医学院附属儿童医院儿童保健科,国家儿童健康与疾病临床医学研究中心,杭州310005 [2]浙江省疾病预防控制中心免疫规划所,杭州310057 [3]杭州市疾病预防控制中心免疫预防所,杭州310021 [4]杭州市疾病预防控制中心微生物检验科,杭州310021 [5]湖州市疾病预防控制中心,湖州313099 [6]浙江大学医学院附属儿童医院消化科,杭州310005 [7]浙江大学医学院附属邵逸夫医院炎症性肠病中心,杭州310020 [8]嘉兴市疾病预防控制中心,嘉兴314050 [9]衢州市疾病预防控制中心,衢州324003 [10]温州市疾病预防控制中心,温州325000 [11]浙江省疾病预防控制中心疾病监测所,杭州310057 [12]中山大学附属第一医院儿科,广州510062 [13]浙江省疾病预防控制中心传染病防治所,杭州310057 [14]郑州大学附属肿瘤医院胃肠肿瘤外科,郑州450000 [15]安徽省疾病预防控制中心,合肥230000 [16]北京协和医院肿瘤内科,北京100000 [17]重庆医科大学附属儿童医院感染病科,重庆400015 [18]福建省疾病预防控制中心,福州350001 [19]河北省疾病预防控制中心,石家庄050024 [20]湖北国际旅行卫生保健中心,武汉430070 [21]华中科技大学同济医学院附属同济医院消化科,武汉430030 [22]江苏省国际旅行保健中心,泰州225401 [23]江苏省疾病预防控制中心传染病防治所,南京210009 [24]江西省疾病预防控制中心免疫规划所,南昌330029 [25]内蒙古自治区综合疾病预防控制中心传染病防治所,呼和浩特010020 [26]山东大学齐鲁医院儿科,济南250063 [27]山东省疾病预防控制中心传染病防治所,济南250013 [28]山西省疾病预防控制中心免疫规划科,太原030012 [29]陕西省疾病预防控制中心,西安710054 [30]上海市疾病预防控制中心疫苗临床试验和上市后评价科,上海200051 [31]四川省疾病预防控制中心,成都610044 [32]天津市疾病预防控制中心,天津300011 [33]天津医科大学

出　　处：《中华临床感染病杂志》2023年第6期420-426,共7页Chinese Journal of Clinical Infectious Diseases

摘　　要：肠产毒性大肠埃希菌(ETEC)感染后表现为水样腹泻,严重者可致脱水、电解质失衡并导致死亡。重组B亚单位/灭活菌体霍乱(rBS/WC)疫苗是预防ETEC感染性腹泻的有效手段。国家儿童健康与疾病临床医学研究中心(浙江大学医学院附属儿童医院)和浙江省疾病预防控制中心组织国内临床医学、预防医学领域的专家参考有关病原学、流行病学、疫苗效果、安全性,以及卫生经济学等方面最新循证证据,制订了rBS/WC疫苗预防ETEC感染性腹泻的专家共识,指导临床医师和预防接种专业人员科学、规范接种疫苗,降低ETEC感染性腹泻的发病率。Enterotoxigenic Escherichia coli(ETEC)infection can induce watery diarrhea,leading to dehydration,electrolyte disturbance,and even death in severe cases.Recombinant B subunit/inactivated whole-cell cholera(rBS/WC)vaccine is effective in preventing ETEC infectious diarrhea.On the basis of the latest evidence on etiology and epidemiology of ETEC,as well as the effectiveness,safety,and health economics of rBS/WC vaccine,National Clinical Research Center for Child Health(The Children’s Hospital,Zhejiang University School of Medicine)and Zhejiang Provincial Center for Disease Control and Prevention invited experts to develop expert consensus on rBS/WC vaccine in prevention of ETEC infectious diarrhea.It aims to provide the clinicians and vaccination professionals with guidelines on using rBS/WC vaccine to reduce the incidence of ETEC infectious diarrhea.

关 键 词：肠产毒性大肠埃希菌 重组B亚单位/灭活菌体霍乱疫苗 感染性腹泻 共识 

分 类 号：R186[医药卫生—流行病学]