血清proBNP和Hcy在冠心病合并高血压中的研究进展  

Progress of serum proBNP and Hcy in coronary heart disease complicated with hypertension

作　　者：王振昌 张奇峰[2,3] WANG Zhenchang;ZHANG Qifeng(The First Clinical Medical College,Guangdong Medical University,Zhanjiang,Guangdong 524023,China;Cardiovascular Research Center,Meizhou People's Hospital,Meizhou,Guangdong 514031,China;Meizhou Clinical Medical College,Guangdong Medical University,Meizhou,Guangdong 514031,China)

机构地区：[1]广东医科大学第一临床医学院,广东湛江524023 [2]梅州市人民医院心血管病研究中心,广东梅州514031 [3]广东医科大学梅州临床医学院,广东梅州514031

出　　处：《医药前沿》2024年第5期26-28,共3页Journal of Frontiers of Medicine

摘　　要：高血压是临床上极为常见的一种心血管疾病,且该类患者往往合并了冠心病,这直接导致了心血管事件的发生风险倍增。目前大量研究表明血清脑钠肽前体(proBNP)、同型半胱氨酸(Hcy)与冠心病合并高血压患者左心室几何构型和功能的异常密切相关。本文就血清proBNP和Hcy的概念、在冠心病和高血压诊断中的临床应用、与冠心病和高血压的关系、引起左心室几何构型及功能异常的机制、指导冠心病合并高血压的治疗进行综述,为预防左心室异常提供参考依据。Hypertension is a highly common cardiovascular disease in clinical practice,and patients with this condition often have concomitant coronary heart disease,directly leading to a twofold increase in the risk of cardiovascular events.Numerous studies currently indicate a close association between serum pro-brain natriuretic peptide(proBNP)and homocysteine(Hcy)levels and the abnormal left ventricular geometry and function in patients with hypertension combined with coronary heart disease.This article provides a review of the concepts of serum proBNP and Hcy,their clinical applications in the diagnosis of coronary heart disease and hypertension,their relationships with coronary heart disease and hypertension,the mechanisms underlying the development of abnormal left ventricular geometry and function,and guidance for the treatment of hypertension combined with coronary heart disease.The aim is to offer a reference for the prevention of left ventricular abnormalities.

关 键 词：综述 血清脑钠肽前体 同型半胱氨酸 冠心病合并高血压 左心室几何构型 左心室功能 

分 类 号：R541.4[医药卫生—心血管疾病]