米拉贝隆联合奥昔布宁在膀胱过度活动症患者中的应用效果观察  

Observation on the effect of mirabegron combined with oxybutynin in patients with overactive bladder

作　　者：彭梅康 陈涛[1] 彭洪亮[1] PENG Mei-kang;CHEN Tao;PENG Hong-liang(Department of Urology,the Fourth Hospital of Changsha,Changsha 410000,China)

机构地区：[1]长沙市第四医院泌尿外科,长沙410000

出　　处：《中国处方药》2024年第2期126-129,共4页Journal of China Prescription Drug

基　　金：湖南省卫健委项目(202304056847)。

摘　　要：目的探究米拉贝隆联合奥昔布宁在膀胱过度活动症患者中的应用效果。方法选取2020年~2022年收治的膀胱过度活动症患者105例,按照随机数字法分为对照组(n=52)和观察组(n=53),其中对照组给予米拉贝隆治疗,观察组采用米拉贝隆联合奥昔布宁治疗。比较两组临床疗效、相关症状评分、心理状态、疾病指标情况及不良反应发生率。结果观察组总有效率(96.23%)高于对照组(80.77%)(P<0.05);治疗后,两组国际前列腺症状评分(IPSS)、储尿期症状评分(USPSS)、排尿期症状评分(VSS)及膀胱过度活动症评价量表(OABSS)评分均下降,且观察组低于对照组(P<0.05);治疗后,两组患者的抑郁自评量表(SDS)、焦虑自评量表(SAS)评分均下降,且观察组低于对照组(P<0.05);观察组的排尿量情况、平均尿流率、最大尿流率、膀胱顺应性及最大膀胱压测定容量均优于对照组(P<0.05);观察组不良反应发生率(7.55%)低于对照组(19.23%),但差异无统计学意义(P>0.05)。结论采用米拉贝隆联合奥昔布宁治疗膀胱过度活动症患者效果显著,能够缓解排尿期症状,改善排尿情况,且不会增加不良反应发生情况,减少患者的负面情绪。Objective To explore the effect of mirabegron combined with oxybutynin in patients with overactive bladder.Methods 105 cases of patients with overactive bladder in a hospital from 2020 to 2022 were selected and divided into control group(n=52)and observation group(n=53)according to random number method.The control group was treated with mirabegron,and the observation group was treated with mirabegron combined with oxybutynin.The clinical efficacy,related symptom scores,psychological state,disease indicators and incidence of adverse reactions were compared between the two groups.Results The total effective rate of observation group(96.23%)was higher than that of control group(80.77%)(P<0.05).After treatment,IPSS,UPSS,VSS and OABSS scores of two groups were decreased,and observation group was lower than control group(P<0.05).After treatment,SDS and SAS scores of both groups were decreased,and observation group was lower than control group(P<0.05).Urine volume,mean urine flow rate,maximum urine flow rate,bladder compliance and maximum bladder pressure measurement volume in observation group were better than those in control group(P<0.05).The incidence of adverse reactions in observation group(7.55%)was lower than that in control group(19.23%),but there was no significant difference(P>0.05).Conclusion In patients with overactive bladder,mirabegron combined with oxybutynin has a significant effect,which can relieve the symptoms of urination and improve the urination condition without increasing the occurrence of adverse reactions,and thus reduce the negative emotions of patients.

关 键 词：膀胱过度活动症 奥昔布宁 米拉贝隆 联合治疗 心理状态 

分 类 号：R694[医药卫生—泌尿科学]