中药辅助治疗的原发性肝胆恶性肿瘤的中医证型及相关因素分析  

Analysis of traditional Chinese medicine syndromes and related factors in primary hepatobiliary malignancies treated with traditional Chinese medicine

作　　者：刘珍珍 潘玉真[2] 朱颖[2] LIU Zhen-zhen;PAN Yu-zhen;ZHU Ying(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;不详)

机构地区：[1]辽宁中医药大学,沈阳110847 [2]辽宁中医药大学附属医院,沈阳110032

出　　处：《中国处方药》2024年第2期149-153,共5页Journal of China Prescription Drug

摘　　要：目的探讨中药辅助治疗的原发性肝胆恶性肿瘤患者的中医证型分布以及性别、年龄、手术史、治疗史、是否发生远处转移等因素与证型分布的相关性。方法回顾性分析2018年1月~2023年2月在某院住院接受中药辅助治疗的原发性肝胆恶性肿瘤患者的临床资料,用统计学软件分析中医证型的分布规律及研究一般资料、手术史、治疗史等因素与中医证型的相关情况。结果研究共纳入60例患者,中医证型分布规律为:肝郁脾虚证>气滞血瘀证>肝胆湿热证>肝肾阴虚证>水湿内停证,中医证型在化疗史、靶向治疗史、免疫治疗史、是否发生淋巴结转移的分布差异有统计学意义(P<0.05),在性别、年龄、手术史以及是否发生远处转移的分布差异无统计学意义(P>0.05)。多因素回归分析发现,是否免疫治疗是影响肝郁脾虚证的独立因素,是否化疗、是否免疫治疗以及是否淋巴结转移是影响气滞血瘀证的独立因素。结论中药辅助治疗的原发性肝胆恶性肿瘤患者的中医证型以肝郁脾虚最多,治疗史和患者是否发生淋巴结转移与中医证型分布相关,未接受免疫治疗的患者易发展为肝郁脾虚证,接受化疗或免疫治疗易导致患气滞血瘀证的风险增加。Objective To explore the distribution of Chinese medicine patterns in patients with primary hepatobiliary malignancies treated with Chinese medicine adjuvant therapy and the correlation between factors such as gender,age,surgical history,treatment history,and whether distant metastasis occurred and the distribution of patterns.Methods The clinical data of patients with primary hepatobiliary malignancies who were hospitalized in a hospital to receive Chinese medicine-assisted treatment from January 2018 to February 2023 were retrospectively analyzed,and the distribution pattern of Chinese medicine patterns and the correlation between factors such as general information,surgical history,and treatment history and Chinese medicine patterns were studied using statistical software.Results A total of 60 patients were included in the study,and the distribution pattern of Chinese medicine patterns was as follows:liver depression and spleen deficiency pattern>qi stagnation and blood stasis pattern>liver and gallbladder damp-heat pattern>liver and kidney yin deficiency pattern>water-dampness internal stagnation pattern,and the differences in the distribution of Chinese medicine patterns in terms of history of chemotherapy,history of targeted therapy,history of immunotherapy,and whether or not lymph node metastasis had occurred were statistically significant(P<0.05),while the differences in the distribution in terms of gender,age,history of surgery,and whether or not distant metastasis had occurred were not statistically significant(P>0.05).Multivariate regression analysis found that whether or not immunotherapy was an independent factor affecting the evidence of liver depletion and spleen deficiency,and whether or not chemotherapy,whether or not immunization,and whether or not lymph node metastasis were independent factors affecting the evidence of qi stagnation and blood stasis.Conclusion The Chinese medicine patterns of patients with primary hepatobiliary malignancies treated with adjuvant Chinese medicine were predominan

关 键 词：原发性肝胆恶性肿瘤 中医证型 相关因素 

分 类 号：R273[医药卫生—中西医结合]