腹膜透析患者发生超滤衰竭相关危险因素分析  

Risk factors of ultrafiltration failure in patients undergoing peritoneal dialysis

作　　者：王书龙[1] 谭红梅 王劭亮[1] 汪次奎 王娟 袁俊峰[1] Wang Shulong;Tan Hongmei;Wang Shaoliang;Wang Cikui;Wang Juan;Yuan Junfeng(Department of Urology,Hubei Provincial Corps Hospital of Chinese People's Armed Police Forces,Wuhan 430061,Hubei Province,China;Center for Blood Purification,General Hospital of Central Theater Command,Wuhan 430010,Hubei Province,China)

机构地区：[1]武警湖北省总队医院泌尿外科,武汉430061 [2]中部战区总医院血液净化科,武汉430010

出　　处：《中国基层医药》2024年第2期191-195,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨持续不卧床腹膜透析(CAPD)患者超滤衰竭(UFF)的发生情况及其相关危险因素。方法回顾性分析武警湖北省总队医院和中部战区总医院2016年1月至2021年12月行CAPD治疗的患者65例的临床资料,分析患者病史、吸烟史、腹膜透析龄、腹膜炎发生率、血红蛋白、白蛋白、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、总胆固醇、三酰甘油等临床指标。采用单因素和多因素回归分析CAPD患者发生UFF与临床指标的相关性。结果65例CAPD患者中,UFF发生率为35.4%(23/65)。UFF组与无UFF组腹膜透析龄、腹膜炎、2型糖尿病史、血清白蛋白、低密度脂蛋白胆固醇、三酰甘油差异均有统计学意义(t=-5.04,χ^(2)=11.51、6.83,t=5.91、-3.28、-2.83,均P<0.05)。多因素回归分析显示,白蛋白与UFF呈负相关(r=-1.06,P<0.05),腹膜透析龄、低密度脂蛋白胆固醇、腹膜炎与UFF呈正相关(r=0.43、2.20、1.67,均P<0.05)。结论腹膜透析龄、腹膜炎、低密度脂蛋白胆固醇是CAPD患者发生UFF的危险因素,白蛋白是阻止CAPD患者发生UFF的保护性因素。Objective To investigate the incidence and risk factors of ultrafiltration failure(UFF)in patients undergoing continuous ambulatory peritoneal dialysis(CAPD).Methods The clinical data of 65 patients undergoing CAPD at the Hubei Provincial Corps Hospital of Chinese People's Armed Police Forces and the General Hospital of Central Theater Command from January 2016 to December 2021 were retrospectively analyzed.The clinical data included patient history,smoking history,duration of peritoneal dialysis,incidence of peritonitis,levels of hemoglobin,albumin,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,total cholesterol,and triglyceride.Univariate and multivariate regression analyses were conducted to investigate the correlation between UFF and various indicators in patients undergoing CAPD.Results Among the 65 patients undergoing CAPD,the incidence of UFF was 35.4%(23/65).There were significant differences in duration of peritoneal dialysis,history of peritonitis,history of type 2 diabetes mellitus,serum albumin,low-density lipoprotein cholesterol,and triglyceride between patients with UFF and those without UFF(t=-5.05,χ^(2)=11.51,6.83,t=5.91,-3.28,-2.83,all P<0.05).Multivariate regression analysis showed that albumin was negatively correlated with UFF(r=-1.06,P<0.05),while duration of peritoneal dialysis,level of low-density lipoprotein cholesterol,and peritonitis were positively correlated with UFF(r=0.43,2.20,1.67,all P<0.05).Conclusion Peritoneal dialysis duration,peritonitis,and low-density lipoprotein cholesterol are risk factors for UFF in patients undergoing CAPD,while albumin is a protective factor against UFF in these patients.

关 键 词：腹膜透析 持续不卧床 超滤 血清白蛋白 腹膜炎 胆固醇 甘油三酯类 因素分析 统计学 

分 类 号：R459.5[医药卫生—治疗学]