痰浊饮治疗早期2型糖尿病肾病疗效观察及对Cys-C、CRP、UAER、CCr水平的影响  

Efficacy of Tanzhuo Decoction in the treatment of early diabetic nephropathy in patients with type 2 diabetes mellitus and its effect on cystatin C,C-reactive protein,urinary albumin excretion rate,and creatinine clearance rate

作　　者：余宏伟 潘中良 范绍荣 徐国强 Yu Hongwei;Pan Zhongliang;Fan Shaorong;Xu Guoqiang(First Department of Internal Medicine,Maanshan Hospital of Traditional Chinese Medicine,Maanshan 243000,Anhui Province,China)

机构地区：[1]马鞍山市中医院内一科,马鞍山243000

出　　处：《中国基层医药》2024年第2期218-222,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：安徽省马鞍山市医疗卫生领域科技计划(YL-2019-01)。

摘　　要：目的探讨痰浊饮治疗早期2型糖尿病肾病的临床疗效及其对血清胱抑素C(Cys-C)、C反应蛋白(CRP)、尿白蛋白排泄率(UAER)、肌酐清除率(CCr)的影响。方法采用随机对照研究,选取马鞍山市中医院2019-2021年门诊及住院治疗的早期2型糖尿病肾病患者80例为研究对象,采用随机数字表法分为对照组40例和治疗组40例。对照组予控制血糖、血压等常规治疗,治疗组在对照组基础上加用自拟中药方痰浊饮治疗,两组疗程30 d。比较两组临床疗效及治疗前后血清Cys-C、CRP、UAER、CCr的变化。结果治疗组总有效率为92.5%(37/40),高于对照组的75.0%(30/40),差异有统计学意义(χ^(2)=4.50,P<0.05)。治疗后,治疗组Cys-C(2.04±0.08)mg/L、CRP为(3.97±1.71)mg/L、UAER(91.18±18.68)µg/min均较治疗前下降(t=12.14、5.59、4.73,均P<0.05),CCr(56.3±5.01)mL/min较治疗前升高(t=-8.56,P<0.05);对照组Cys-C(2.17±0.04)mg/L、CRP(4.66±1.47)mg/L、UAER(103.93±22.62)µg/min均较治疗前下降(t=4.05、5.00、2.24,均P<0.05),CCr(45.9±4.9)mL/min较治疗前升高(t=-3.98,P<0.05),治疗组Cys-C、UAER、CCr与对照组比较,差异均有统计学意义(t=-7.42、-2.29、7.82,均P<0.05)。结论痰浊饮治疗早期2型糖尿病肾病疗效确切,能够有效降低Cys-C、UAER的水平,抑制机体炎症反应,改善肾功能,延缓肾功能损害的进一步发展。Objective To investigate the efficacy of Tanzhuo Decoction in the treatment of early diabetic nephropathy in patients with type 2 diabetes mellitus and its effect on cystatin C(Cys-C),C-reactive protein(CRP),urinary albumin excretion rate(UAER),and creatinine clearance rate(CCr).Methods Eighty patients with type 2 diabetes mellitus complicated by early diabetic nephropathy who received treatment at Maanshan Hospital of Traditional Chinese Medicine from 2019 to 2021 were included in this randomized controlled study.They were divided into a control group(n=40)and a treatment group(n=40)using the random number table method.Patients in the control group received conventional therapy including blood glucose and blood pressure control,while those in the treatment group received Tangzhuo Decoction in addition to the same treatment as that given to the control group.Both groups of patients were treated for 30 days.The clinical efficacy as well as pre-and post-treatment Cys-C,CRP,UAER,and CCr were compared between the two groups.Results The total response rate in the treatment group was 92.5%(37/40),which was significantly higher than 75.0%(30/40)in the control group(χ^(2)=4.50,P<0.05).After treatment,Cys-C,CRP,and UAER in the treatment group were(2.04±0.08)mg/L,(3.97±1.71)mg/L,and(91.18±18.68)µg/min,respectively,which were significantly decreased compared with those before treatment(t=12.14,5.59,4.73,all P<0.05).After treatment,CCr in the treatment group was(56.3±5.01)mL/min,which was significantly increased compared with that before treatment(t=-8.56,P<0.05).After treatment,Cys-C,CRP,and UAER in the control group were(2.17±0.04)mg/L,(4.66±1.47)mg/L,and(103.93±22.62)µg/min,respectively,which were significantly decreased compared with those before treatment(t=4.05,5.00,2.24,all P<0.05).After treatment,CCr in the control group was(45.9±4.9)mL/min,which was significantly increased compared with that before treatment(t=-3.98,P<0.05).There were significant differences in Cys-C,UAER,and CCr between the treatment and

关 键 词：糖尿病肾病 C反应蛋白质 白蛋白尿 血糖 血压 医学 中国传统 疗效比较研究 

分 类 号：R259[医药卫生—中西医结合] R277.5[医药卫生—中医内科学]