结核分枝杆菌诱导IFN-β产生在免疫调控中的作用  

Research progress in the role of IFN-βproduction induced by Mycobacterium tuberculosis in immune regulation

作　　者：黄蓓 孟祥苗 田江瑶 宋厚辉 杨杨 HUANG Bei;MENG Xiangmiao;TIAN Jiangyao;SONG Houhui;YANG Yang(China-Australia Joint Laboratory for Animal Health Big Data Analytics,Key Laboratory of Applied Technology on Green-eco-healthy Animal Husbandry of Zhejiang Province,Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management,Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics&Advanced Technology,College of Animal Science and Technology&College of Veterinary Medicine,Zhejiang A&F University,Hangzhou 311300,Zhejiang,China)

机构地区：[1]浙江农林大学动物科技学院·动物医学院动物健康互联网检测技术浙江省工程研究中心、浙江省动物医学与健康管理国际科技合作基地、浙江省畜禽绿色生态健康养殖应用技术研究重点实验室、中澳动物健康大数据分析联合实验室,浙江杭州311300

出　　处：《微生物学报》2024年第2期331-343,共13页Acta Microbiologica Sinica

基　　金：浙江省自然科学基金(LTGD23C180001);浙江农林大学学校科研发展基金(2022LFR067);浙江省属高校基本科研业务费专项基金(2020YQ008);国家自然科学基金(32272951)。

摘　　要：结核分枝杆菌是导致结核病的病原体,也是影响全球数百万人健康的病原体之一。机体中多种模式识别受体(pattern recognition receptor,PRR)可识别入侵的结核分枝杆菌,如DNA和RNA传感器,从而激活天然免疫系统并诱导干扰素-β(interferon-β,IFN-β)产生。虽然IFN-β是先天抗病毒应答的主要效应因子,但其在结核分枝杆菌感染中的作用仍具有争议。结核分枝杆菌感染诱导的IFN-β产生可以促进细菌生长,并增强细菌在宿主中的存活率,但用IFN-β处理细胞后再感染结核分枝杆菌,则可增强抗菌作用,保护宿主。因此,本综述将重点关注可识别结核分枝杆菌并诱导的IFN-β产生的PRR及其下游信号通路,并着重探讨IFN-β在介导结核分枝杆菌调控免疫功能中的作用,尤其是IFN-β与IL-1β之间的相互抑制性调节,旨在为进一步揭示结核分枝杆菌致病机制及结核病治疗药物研发提供新思路。Mycobacterium tuberculosis(Mtb),the pathogen of tuberculosis(TB),threatens the health of millions of people worldwide.The pattern recognition receptors(PRRs)including DNA and RNA sensors on immune cells recognize the invaded Mtb to activate the innate immune system and induce the production of interferon-beta(IFN-β).IFN-βis a major effector cytokine in innate antiviral response,while its role in the host response to Mtb infection remains controversial.IFN-βinduced by Mtb can promote bacterial growth and improve the bacterial survival in the host.However,IFN-βtreatment before Mtb infection can protect the host from bacterial infection.Focusing on the PRR signaling pathways that can recognize Mtb and mediate the IFN-βproduction,this review expounds the role of IFN-βin mediating the regulation of immune function by Mtb,especially the mutual inhibitory effect between IFN-βand IL-1β,aiming to reveal the pathogenic mechanism of Mtb and facilitate future research and development of anti-TB drugs.

关 键 词：结核分枝杆菌 干扰素Β 信号通路 

分 类 号：R52[医药卫生—内科学] R-332[医药卫生—临床医学]