超声弹性评分联合血清甲状腺球蛋白水平对老年甲状腺癌患者治疗预后的预测价值  

Predictive Value of Ultrasound Elasticity Score Combined with Serum Thyroglobulin Level in Elderly Thyroid Cancer Patients

作　　者：程亚南[1] 杨金雨 郭晓磊[1] 刘婷 杨青[1] CHENG Yanan;YANG Jinyu;GUO Xiaolei(The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第五附属医院,450000

出　　处：《实用癌症杂志》2024年第3期454-457,共4页The Practical Journal of Cancer

摘　　要：目的分析超声弹性评分与血清甲状腺球蛋白(Tg)水平联合预测老年甲状腺癌(TC)患者治疗预后的效用。方法选取76例老年TC患者,术前均行超声检查,并行超声弹性评分。于术后1年测定患者血清的Tg水平,分析不同临床病理特征的超声弹性评分与血清Tg水平;同时绘制受试者工作曲线(ROC),分析超声弹性评分、血清Tg水平单独与联合预测老年TC患者术后淋巴结转移的效能;另对比不同超声弹性评分与血清Tg水平患者无进展生存期。结果术后发生淋巴结转移患者术前超声弹性评分高于无淋巴结转移者,术后发生淋巴结转移患者术后1年的血清Tg水平高于无淋巴结转移者,有统计学差异(P<0.05)。ROC结果显示:超声弹性评分、血清Tg水平联合检测预测老年TC患者术后淋巴结转移的曲线下面积(AUC),高于两种方法单独检测。超声弹性评分<3.5分与血清Tg水平<24.995μg老年TC患者的无进展生存期高于超声弹性评分≥3.5分与血清Tg水平≥24.995μg的患者,有统计学差异(P<0.05)。结论超声弹性评分联合血清Tg水平可预测老年TC患者治疗预后。Objective To analyze the utility of combining ultrasound elasticity score and serum thyroglobulin(Tg)levels in predicting the treatment prognosis of elderly thyroid cancer(TC)patients.Methods 76 elderly patients with TC were selected,and all underwent preoperative ultrasound examination and ultrasound elasticity score.Measure the patient's serum Tg levels one year after surgery,and analyze the ultrasound elasticity score and serum Tg levels for different clinical and pathological features;Simultaneously draw the receiver operating curve(ROC)and analyze the efficacy of ultrasound elasticity score and serum Tg level alone and in combination in predicting postoperative lymph node metastasis in elderly TC patients;Compared the progression free survival time of patients with different ultrasound elasticity scores and serum Tg levels.Results The preoperative ultrasound elasticity score of patients with postoperative lymph node metastasis was higher than that of those without lymph node metastasis.The serum Tg level of patients with postoperative lymph node metastasis was higher than that of those without lymph node metastasis one year after surgery,with a statistical difference(P<0.05).The ROC results showed that the combined detection of ultrasound elasticity score and serum Tg level predicted the area under the curve(AUC)of postoperative lymph node metastasis in elderly patients with TC,which was higher than the 2 methods tested separately.The progression free survival of elderly TC patients with ultrasound elasticity score<3.5 and serum Tg level<24.995μg was higher than that of patients with ultrasound elasticity score≥3.5 and serum Tg level≥24.995μg,there was a statistical difference(P<0.05).Conclusion The combination of ultrasound elasticity score and serum Tg level measurement can predict the treatment prognosis of elderly TC patients.

关 键 词：老年甲状腺癌 超声弹性评分 甲状腺球蛋白 预后 

分 类 号：R736.1[医药卫生—肿瘤]