运动心肺试验低通气效率在慢性阻塞性肺疾病中的研究进展  

Advances in research on impaired ventilatory efficiency in cardiopulmonary exercise testing and chronic obstructive pulmonary disease

作　　者：邓志珊 吴繁 宛琪 周玉民 冉丕鑫 Deng Zhishan;Wu Fan;Wan Qi;Zhou Yumin;Ran Pixin(Guangzhou Institute of Respiratory Health(National Clinical Research Center for Respiratory Disease,State Key Laboratory of Respiratory Disease,National Center for Respiratory Medicine),The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou 510120,China;Guangzhou National Laboratory,Guangzhou Institute of Respiratory Health(National Clinical Research Center for Respiratory Disease,State Key Laboratory of Respiratory Disease,National Center for Respiratory Medicine),The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou 510005,China)

机构地区：[1]呼吸疾病全国重点实验室、国家呼吸系统疾病临床医学研究中心、国家呼吸医学中心、广州呼吸健康研究院、广州医科大学附属第一医院、广州医科大学,广州510120 [2]广州国家实验室、呼吸疾病全国重点实验室、国家呼吸系统疾病临床医学研究中心、国家呼吸医学中心、广州呼吸健康研究院、广州医科大学附属第一医院、广州医科大学,广州510005

出　　处：《中华结核和呼吸杂志》2024年第2期167-171,共5页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：广东省“珠江人才计划”本土创新科研团队项目(2017BT01S155);“十三五”国家重点研发计划(2016YFC1304101);广州国家实验室自立项目(SRPG22-016,SRPG22-018);呼吸疾病全国重点实验室临床及流行病学研究专项(SKLRD-L-202402)。

摘　　要：运动心肺试验中低通气效率的相关病理生理学机制及临床应用是目前国内外慢性阻塞性肺疾病的研究热点之一,越来越多证据证明低通气效率与慢阻肺劳力性呼吸困难、运动耐量下降和死亡高风险有关。通气效率有望成为缓解慢阻肺患者呼吸困难症状的新的治疗靶点。本文就低通气效率在慢阻肺中的研究进展进行综述,以增加对低通气效率的慢阻肺患者的认识,更好地为这类患者提供综合全面的评估和管理。The investigation of the pathophysiological mechanisms and potential applications of impaired ventilatory efficiency in cardiopulmonary exercise testing has received considerable attention in the field of chronic obstructive pulmonary disease(COPD)research worldwide.A growing body of evidence supports the notion that impaired ventilatory efficiency is an important indicator of exertional dyspnea,reduced exercise capacity,and mortality in patients with COPD.As a result,ventilatory efficiency is emerging as a promising therapeutic target for alleviating dyspnea in COPD patients.This review aims to provide a comprehensive summary of the research progress into impaired ventilatory efficiency in patients with COPD.The primary objective of this review is to improve the understanding of COPD patients with impaired ventilatory efficiency,with the ultimate goal of facilitating the comprehensive assessment and management of COPD.

关 键 词：呼吸困难症状 通气效率 慢性阻塞性肺疾病 运动耐量 慢阻肺患者 劳力性呼吸困难 运动心肺试验 治疗靶点 

分 类 号：R563.9[医药卫生—呼吸系统]