幽门螺杆菌感染静态和动态低频振幅rs-fMRI研究  

Static and Dynamic Low-Frequency Amplitude rs-fMRI Study of Helicobacter Pylori Infection

作　　者：巨妍 王嵩[1] JU Yan;WANG Song(Department of Radiology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,P.R.China)

机构地区：[1]上海中医药大学附属龙华医院放射科,200032

出　　处：《临床放射学杂志》2024年第1期17-21,共5页Journal of Clinical Radiology

基　　金：上海市自然基金项目(编号:19ZR1457800)。

摘　　要：目的探究幽门螺杆菌(Hp)感染后自发脑活动特征。方法纳入年龄、性别、受教育年限、胃部疾病情况相匹配的Hp阳性组(n=29)和对照组(n=29),采集静息态功能磁共振成像数据,基于Matlab2017b的DPABI软件和DynamicBC软件分别进行两组间静态(sALFF)、动态低频振幅(dALFF)分析,并提取差异脑区值与胃肠道症状评定量表(GSRS)做相关性分析。结果与对照组相比,Hp阳性组左侧中央旁小叶、左侧中央后回和右侧丘脑sALFF值升高;枕叶、右侧颞叶以及右侧丘脑dALFF时间变异性增强(GRF校正,体素水平P<0.005,团块水平P<0.05)。右侧丘脑dALFF值与GSRS评分呈正相关(P=0.041,r=0.269),其他差异脑区未见显著相关。结论Hp阳性患者表现出脑活动强度和稳定性异常,结果既存在重叠又互相补充,提示sALFF和dALFF指标结合可一定程度反映Hp感染患者脑活动功能改变情况。Objective To explore the characteristics of spontaneous brain activity after Helicobacter pylori(Hp)infec-tion.Methods The Hp-positive group(n=29)and the control group(n=29)matched with age,sex,years of education and stomach disease were included.rs-fMRI data were collected.The static(sALFF)and dynamic low-frequency amplitude(dALFF)analyses between the two groups were carried out based on the DPABI software of Matlab2017b and the Dynam-icBC software,and the correlation analysis between the difference brain area values and the Upper Gastrointestinal Symptoms Rating Scale(GSRS)was conducted.Results Compared with the control group,sALFF value of left paracentral lobule,left posterior central gyrus and right thalamus increased in Hp positive group.dALFF time variability increased in occipital lobe,right temporal lobe and right thalamus(GRF correction,voxel level P<0.005,mass level P<0.05).dALFF value of right thalamus was positively correlated with GSRS score(P=0.041,r=0.269),but no significant correlation was found in other different brain regions.Conclusion Hp positive patients showed abnormal intensity and stability of brain activity,and the results were overlapping and complementary,suggesting that the combination of sALFF and dALFF indexes could re-flect the changes of brain activity and function in Hp infected patients to a certain extent.

关 键 词：幽门螺杆菌 静息态功能磁共振成像 低频振幅 肠-脑轴 

分 类 号：R445.2[医药卫生—影像医学与核医学] R57[医药卫生—诊断学]