sBTFE序列在体内正常胎脑和异质性改变胎脑的应用研究  

The Heterogeneous Alteration in Normal Fetal Brain in Vivo and in Utero Revealed by sBTFE Sequence

作　　者：李茗[1] 李想[1] 胡安宁[1] 陆芳菲[1] 薛巽文 蒋雯欣 韩小伟 费强[1] LI Ming;LI Xiang;HU Anning(Department of Medical Imaging,Gulou Hospital,Nanjing University School of Medicine,Nanjing 210008,P.R.China)

机构地区：[1]南京大学医学院附属鼓楼医院医学影像科,210008

出　　处：《临床放射学杂志》2024年第1期120-124,共5页Journal of Clinical Radiology

基　　金：国家自然科学基金项目(编号:81720108022);国家自然科学基金项目(编号:91649116);南京市医学科技发展资金项目(编号:YKK16112)。

摘　　要：目的探讨具有灵敏度编码的快速平衡稳态梯度场回波(sBTFE)序列对测量胎脑白质信号强度(SI)及胎脑白质改变中的应用价值。方法对160例在21~39孕周的异质性胎脑进行sBTFE序列1.5T扫描。根据胎龄将胎儿大脑分为4组(A~D组),分别计算每个胎龄组双侧前额叶、枕叶、颞叶、顶叶和中央前白质区以及丘脑、小脑和脑桥的信号强度比值(SIRs),并用方差分析方法对上述感兴趣内SIRs的组间差异进行评估。结果sBTFE具有良好的脑脊液白质对比度和较高的空间分辨率,对胎脑白质的成像具有最佳的诊断信度(3.35±0.42)。结论sBTFE序列显示了胎脑白质SIR随胎龄的不同而不同,反映了生发基质何时何地迁移以及髓鞘形成过程的时间顺序。Objective To explore the application value of the fast balanced steady-state gradient field echo(sBTFE)sequence with sensitivity coding for measuring the signal intensity(SI)and fetal white matter changes.Methods A sBT-FE sequence 1.5T scan was performed on 160 heterogeneous fetal brains at 21 to 39 weeks of gestation.Fetal brains were divided into four groups of A-D according to gestational age,calculated signal intensity ratios(SIRs)for bilateral prefron-tal,occipital,temporal,parietal and parietal precentral white matter regions,thalamus,cerebellum and pons for each gesta-tional age group,and group differences in SIRs of interest were assessed by ANOVA.Results The sBTFE has good CSF white matter contrast and high spatial resolution,providing optimal diagnostic reliability for imaging the fetal brain white matter(3.35±0.42).Conclusion The sBTFE sequence shows that the fetal brain white matter SIR varies with gesta-tional age,reflecting when and where the germinal matrix migrated and the temporal order of the myelination process.

关 键 词：活体胎儿颅脑成像 白质改变 信号强度比 快速平衡稳态梯度场回波 脑内连通性 

分 类 号：R445.2[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]