纳米长余辉发光材料在生物医学检测、生物成像与肿瘤治疗中的研究进展  

Research Progress of Persistent Luminescent Nanoparticles in Biomedical Detection,Bioimaging and Tumor Therapy

作　　者：王俊 张兵波[2] WANG Jun;ZHANG Bingbo(The Department of Clinical Laboratory Medicine,Southwest Hospital,Army Medical University,Chongqing 400038,China;Department of Radiology,Tongji Hospital,Shanghai Frontiers Science Center of Catalytic Medicine,The Institute for Biomedical Engineering and Nano Science,School of Medicine,Tongji University,Shanghai 200065,China)

机构地区：[1]陆军军医大学,西南医院检验科,重庆400038 [2]同济大学附属同济医院放射科,上海市催化医学前沿科学研究基地,同济大学医学院生物医学工程与纳米科学研究院,上海200065

出　　处：《发光学报》2024年第2期252-268,共17页Chinese Journal of Luminescence

基　　金：重庆市自然科学基金(CSTB2022NSCQ-MSX0205);国家自然科学基金(82272055)。

摘　　要：长余辉发光材料是一种能储存外界激发光能量、在激发光停止激发后仍能持续发光的材料。由于其长余辉寿命、无需原位激发、无组织背景信号干扰和高信噪比等优点,纳米长余辉发光材料广泛应用于生物医学检测、生物成像和肿瘤治疗领域。本文综述了近年来纳米长余辉发光材料在生物医学检测、生物成像和肿瘤治疗(化疗、光热治疗、光动力治疗和免疫治疗)方面的应用进展,并进一步探讨了其在生物医学应用中所面临的挑战,对其未来的发展趋势也进行了展望。Persistent luminescent materials are photoluminescent materials that can store external light emission energy and continue to emit luminescence after the cessation of excitation.Due to long afterglow lifetime,no need for in-situ excitation,no interference from tissue background signals,and high signal-to-noise ratio,persistent lumines‐cent nanoparticles(PLNPs)are widely used in biomedical detection,biological imaging,and tumor therapy.This ar‐ticle reviews the application progress of the PLNPs in biomedical detection,biological imaging and tumor therapy(chemotherapy,photothermal therapy,photodynamic therapy,and immunotherapy)in recent years,and further ex‐plores the challenges in biomedical applications and prospects the future development trends.

关 键 词：纳米长余辉发光材料 余辉发光 生物医学检测、生物成像 肿瘤治疗 

分 类 号：O482.31[理学—固体物理]