短柱肖菝葜中的3个2,3-二酮喹喔啉类生物碱及其肝保护活性  

Three 2,3-diketoquinoxaline alkaloids with hepatoprotective activity from Heterosmilax yunnanensis

作　　者：杜茸茸 郭馨怡 秦文杰 孙华 段秀梅 苑祥 杨桠楠 李昆 张培成 DU Rong-rong;GUO Xin-yi;QIN Wen-jie;SUN Hua;DUAN Xiu-mei;YUAN Xiang;YANG Ya-nan;LI Kun;ZHANG Pei-cheng(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Beijing Zhendong Guangming Pharmaceutical Research Institute,Beijing 100085,China;Shanxi Zhendong Pharmaceutical Co.Ltd.,Changzhi 047100,China)

机构地区：[1]中国医学科学院,北京协和医学院药物研究所,天然药物活性物质与功能国家重点实验室,北京100050 [2]北京振东光明药物研究院,北京100085 [3]山西振东制药股份有限公司,山西长治047100

出　　处：《药学学报》2024年第2期413-417,共5页Acta Pharmaceutica Sinica

摘　　要：从短柱肖菝葜(Heterosmilax yunnanensis Gagnep.)中分离得到3个2,3-二酮喹喔啉类生物碱,通过一维和二维核磁共振、高分辨质谱、紫外光谱和红外光谱确定其化学结构,分别鉴定为1-[5′-(3″-羟基-3″-甲基)戊二酸单酰基]核糖醇基-2,3-二酮-1,2,3,4-四氢-6,7-二甲基喹喔啉(1)、1-[2′-(3″-羟基-3″-甲基)戊二酸单酰基]核糖醇基-2,3-二酮-1,2,3,4-四氢-6,7-二甲基喹喔啉(2)和1-核糖醇基-2,3-二酮-1,2,3,4-四氢-6,7-二甲基喹喔啉(3)。其中化合物1和2是新化合物,化合物3是首次从短柱肖菝葜中分离得到,通过肝保护活性筛选,发现化合物3具有良好的肝保护活性。Three 2,3-diketoquinoxaline alkaloids were isolated from Heterosmilax yunnanensis Gagnep.Their structures were determined through 1D and 2D NMR,HR-ESI-MS,UV,and IR as 1-[5′-(3″-hydroxy-3″-methyl)glutaryl]ribityl-2,3-diketo-1,2,3,4-tetrahydro-6,7-dimethylquinoxaline(1),1-[2′-(3″-hydroxy-3″-methyl)glutaryl]ribityl-2,3-diketo-1,2,3,4-tetrahydro-6,7-dimethylquinoxaline(2),and 1-ribityl-2,3-diketo-1,2,3,4-tetrahydro-6,7-dimethylquinoxaline(3).Compounds 1 and 2 are novel compounds,and 3 was isolated from H.yunnanensis for the first time.The hepatoprotective activity of these three compounds was evaluated,with compound 3 showing promising hepatoprotective activity.

关 键 词：短柱肖菝葜 百合科 2 3-二酮喹喔啉 肝保护活性 

分 类 号：R284[医药卫生—中药学]