基于玄府理论探讨资生丸治疗脾虚型衰弱综合征的配伍思路及疗效观察  

Discussion on the thoughts on the compatibility of TCM medicine and therapeutic effects of Zisheng Wan on spleen deficiency syndrome based on the theory of Xuanfu

作　　者：胥青梅 李金凤 欧雪梅 王小强 XU Qingmei

机构地区：[1]西南医科大学附属中医医院,四川泸州646000

出　　处：《中医临床研究》2024年第1期70-75,共6页Clinical Journal Of Chinese Medicine

基　　金：西南医科大学校级科研基金自然科学项目(2019ZQN135):基于健脾法探究资生丸对脾虚型老年患者衰弱综合征的影响研究。

摘　　要：目的:基于玄府理论探讨资生丸治疗脾虚型衰弱综合征的配伍思路及临床疗效观察,以期为相关研究提供参考。方法:将总共72例研究对象随机均分为试验组和对照组,每组36例。试验组接受口服资生丸联合常规西医治疗方法,对照组仅接受常规西医治疗。两组均持续用药8周并定期随访。在治疗前后记录患者中医证候积分、衰弱指数量表、微型营养评估量表、日常生活活动能力量表、简明运动测试量表等评分。结果:试验组总有效率为97.2%(35/36),对照组为66.7%(24/36)。与组内治疗前对比,试验组与对照组治疗后的证候积分、衰弱指数量表评分均有所降低,差异具有统计学意义(P<0.05)。微型营养评估量表、日常生活活动能力量表、简明运动测试量表评分均显著提高,差异具有统计学意义(P<0.05)。与对照组治疗后相比,试验组治疗后的证候积分、衰弱指数量表评分更低,差异具有统计学意义(P<0.05),而微型营养评估量表评分更高,差异具有统计学意义(P<0.05),表明试验组方案具有更好的疗效。结论:资生丸可作为脾虚型衰弱综合征中西医结合方案的验方推荐。资生丸具有开通“脾玄府”,闭阖“肾玄府”,防止精气流失的特色配伍,加上辨证和病机用药,从而达到调和先、后天之本来治疗脾虚型衰弱综合征的目的。Objective:To explore the thoughts on the compatibility of TCM medicine and therapeutic effects of Zisheng Wan(资生丸)on spleen deficiency syndrome based on the theory of Xuanfu(玄府),in order to provide reference for related research.Methods:Using the simple randomization grouping method,the 72 study subjects were divided into the test groupO and the control groups.The test group used oral Zisheng Wan plus conventional Western medicine,while the control group was treated in conventional Western medicine only.Both groups continued medication for 8 weeks and regular follow-up.TCM syndrome integral,Frailty Index number scale(FI),micro-nutrition assessment scale(MNA),daily life activity strength scale(ADL),and concise exercise test scale(SPPB)were recorded before and after treatment.Results:The total efficiency was 97.2%(35/36)in the text group and 66.7%(24/36)in the control group.Compared with before treatment,the syndrome score and FI score in the test group and the control group were decreased after treatment,and the difference was statistically significant(P<0.05).The scores of MNA,ADL and SPPB were significantly increased(P<0.05).Compared with the control group after treatment,the syndrome score and FI score in the text group were lower(P<0.05).The score of MNA was more(P<0.05).The results show that the text group has a better curative effect.Conclusion:After the evaluation of integrative medicine,it is found that Zisheng Wan can be recommended as the test prescription of spleen deficiency and weakness syndrome.Zisheng Wan has the characteristics of opening the spleen-Xuanfu,promote the spleen and stomach transport,close the kidney Xuanfu,to prevent the loss of essence and Qi(气)compatibility.In addition,the cause and syndrome differentiation,so as to achieve the purpose of the treatment of spleen deficiency and weakness syndrome.

关 键 词：玄府理论 脾虚证 衰弱综合征 资生丸 

分 类 号：R28[医药卫生—中药学]