2014-2021年陕西省507例人间布鲁氏菌病病例的病原及流行病学特征分析  

Pathogenic and epidemiological characteristics of 507 cases of human brucellosis in Shaanxi Province from 2014 to 2021

作　　者：聂守民 罗波艳 王文静 周地佳 范锁平[1] 安翠红[1] 孙养信[1] Nie Shoumin;Luo Boyan;Wang Wenjing;Zhou Dijia;Fan Suoping;An Cuihong;Sun Yangxin(Institute for Plague and Brucellosis Prevention and Control,Shaanxi Provincial Center for Disease Control and Prevention,Xi'an 710054,China)

机构地区：[1]陕西省疾病预防控制中心鼠疫与布鲁氏菌病防控所,西安710054

出　　处：《中华地方病学杂志》2023年第12期979-983,共5页Chinese Journal of Endemiology

基　　金：陕西省重点研发计划项目(2018SF-001)。

摘　　要：目的探讨陕西省人间布鲁氏菌病病例的病原及流行病学特征,为陕西省人间布鲁氏菌病的科学化防控提供依据。方法自陕西省疾病预防控制中心收集2014-2021年陕西省报告的507例人间布鲁氏菌病病例的病原学培养资料,自中国疾病预防控制信息系统—传染病信息报告管理系统收集病例的流行病学资料,通过Excel 2016软件汇总数据并分析,并利用ArcGIS 10.6软件进行可视化。结果507例病例主要集中在2018-2021年(322例),发病高峰期为5-7月份(255例);主要分布于渭南市(129例)、榆林市(114例)和延安市(97例);职业以农民为主(415例);年龄集中在40~59岁(272例);男女性别比为3.22∶1.00(387∶120);95.46%(484/507)的病例有牛、羊密切接触史,主要为羊接触史(480例);临床症状以发热、乏力、多汗、关节肌肉疼痛多见,肝、脾、睾丸肿大少见;89.55%(454/507)的病例在急性期内得到诊断;试管凝集试验中,1∶200阳性病例最多(139例);经培养分离得到214株布鲁氏菌,出菌率为42.21%,均为羊种布鲁氏菌,其中羊种3型占79.91%(171/214)。结论陕西省人间布鲁氏菌病病例主要通过接触羊而感染,传染源以羊种3型布鲁氏菌为主。Objective To investigate the pathogenic and epidemiological characteristics of human brucellosis in Shaanxi Province,and to provide a basis for scientific prevention and control of human brucellosis in Shaanxi Province.Methods The pathogenic culture data of 507 reported cases of human brucellosis reported in Shaanxi Province from 2014 to 2021 were collected from the Shaanxi Provincial Center for Disease Control and Prevention.The epidemiological data of the cases were collected from the Infectious Disease Information Reporting Management System of China Disease Prevention and Control Information System.The data were summarized and analyzed using Excel 2016 software,and visualized using ArcGIS 10.6 software.Results The 507 cases were concentrated from 2018 to 2021(322 cases),with a peak incidence period from May to July(255 cases).Cases mainly distributed in Weinan City(129 cases),Yulin City(114 cases)and Yan'an City(97 cases).Farmers were the main occupation(415 cases).The cases were mainly aged 40-59(272 cases).The male to female gender ratio was 3.22∶1.00(387∶120).Totally 95.46%(484/507)of the cases had a history of close contact with cattle or sheep,mainly sheep(480 cases).The clinical symptoms included fever,fatigue,hyperhidrosis,joint and muscle pain,with rare liver,spleen and testicular enlargement.Totally 89.55%(454/507)of the cases were diagnosed during the acute phase.In vitro agglutination test,1∶200 positive cases were the most common(139 cases).Totally 214 strains of Brucella were isolated and cultured,and the rate of bacterial production was 42.21%,all of which were Brucella melitensis,of which type 3 accounted for 79.91%(171/214).Conclusion Human brucellosis cases in Shaanxi Province are mainly infected by contact with sheep,with the main source of infection being Brucella melitensis type 3.

关 键 词：布鲁氏菌病 病原学培养 流行病学特征 

分 类 号：R516.7[医药卫生—内科学] R181.3[医药卫生—临床医学]