Potential pharmacological mechanisms of digallate in the treatment of enteritis based on network pharmacology and molecular docking  

作　　者：Ning Tang Lian-Dong Zhao Yang Zhao Yu-Meng Han Yue Cao Yan Wang 

机构地区：[1]Department of Integrative Medicine,Liaoning University of Traditional Chinese Medicine Xinglin College,Shenyang 110167,China [2]Department of Traditional Chinese Medicine,Liaoning University of Traditional Chinese Medicine Xinglin College,Shenyang 110167,China [3]Department of Integrative Medicine,Dalian Medical University,Dalian 116044,China

出　　处：《Integrative Medicine Discovery》2024年第7期1-10,共10页

基　　金：supported by National Science Fund for Young Scholars of China (Grant No.82204594).

摘　　要：Background:In order to investigate the possible pharmacological mechanism of digallate in Galla Chinensis for treating enteritis,providing reference for the search and exploration of effective drugs for treating enteritis.Method:Traditional Chinese Medicines Systems Pharmacology Database and Analysis Platform,PharmMapper,DisGeNET,DrugBank,and GeneCards databases were used to obtain drug and disease-related target information.Gene ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment were performed,and the main therapeutic pathways and targets were identified by combining protein-protein interaction networks and cytoHubba plug-in.Molecular docking was used to validate the results.Result:297 drug related targets,2436 disease related targets,and 66 target points related to digallate were predicted to be associated with enteritis.10 related signal pathways and 10 key genes were identified.Conclusion:Digallate may be utilized to treat enteritis by acting on similar pathways,such those related to pathways in cancer,lipid and atherosclerosis,proteoglycans in cancer,Rap1 signaling pathway,PI3K-Akt signaling pathway and other targets such as IGF1,EGFR,SRC,IGF1R,PPARG.

关 键 词：digallate ENTERITIS network pharmacology molecular docking 

分 类 号：R285[医药卫生—中药学]