过敏性紫癜患儿预后影响因素及其预测价值研究  

Prognostic influencing factors and their predictive value of children with Henoch-Sch nlein purpura

作　　者：刘丽莹 朱影[1] 毛国顺[1] 胡国生[1] 王艳娟 LIU Liying;ZHU Ying;MAO Guoshun;HU Guosheng;WANG Yanjuan(Department of Pediatrics,Fuyang People’s Hospital,Fuyang 236000,China)

机构地区：[1]阜阳市人民医院儿科,安徽阜阳236000 [2]芜湖市第一人民医院儿科,安徽芜湖241000

出　　处：《陕西医学杂志》2024年第3期382-385,共4页Shaanxi Medical Journal

基　　金：安徽省自然科学基金资助项目(2108085MH262)。

摘　　要：目的:探讨过敏性紫癜(HSP)患儿预后的影响因素及其预测价值。方法:选取HSP患儿150例为研究对象。根据患儿治疗后有无复发分为预后不良组(47例)和预后良好组(103例)。比较两组患儿一般资料及生化指标(白细胞计数、血小板计数、血清总蛋白、乳酸脱氢酶、碱性磷酸酶、C-反应蛋白、免疫球蛋白A)。分析HSP患儿预后的影响因素及其对患儿预后不良的预测价值。结果:预后不良组皮疹反复发作、初次发病伴肾损害和呼吸道感染比例高于预后良好组(均P<0.05)。预后不良组血小板计数、C-反应蛋白及免疫球蛋白A水平高于预后良好组(均P<0.05)。皮疹反复发作、初次发病伴肾损害、呼吸道感染、血小板计数、C-反应蛋白及免疫球蛋白A为HSP患儿预后的独立影响因素(均P<0.05)。皮疹反复发作、呼吸道感染、血小板计数、C-反应蛋白及免疫球蛋白A对HSP患儿预后不良具有预测价值(均P<0.05)。结论:皮疹反复发作、初次发病伴肾损害、呼吸道感染、血小板计数、C-反应蛋白及免疫球蛋白A为HSP患儿预后的独立影响因素。除初次发病伴肾损害指标外,其余指标对HSP患儿预后不良具有一定预测价值。Objective:To explore the prognostic influencing factors and their predictive value of children with Henoch-Sch nlein purpura(HSP).Methods:A total of 150 children with HSP were selected as the study objects.The children were divided into poor prognosis group(47 cases)and good prognosis group(103 cases)according to recurrence or not after treatment.General data and biochemical indicators(white blood cell count,platelet count,and serum total protein,lactate dehydrogenase,alkaline phosphatase,C-reactive protein,immunoglobulin A)were compared between the two groups.The prognostic influencing factors and their predictive value for poor prognosis of children with HSP were analyzed.Results:The proportion of recurrent rash,initial onset with kidney damage and respiratory tract infection in the poor prognosis group were higher than those in the good prognosis group(all P<0.05).The levels of platelet count,C-reactive protein and immunoglobulin A in the poor prognosis group were higher than those in the good prognosis group(all P<0.05).Recurrent rash,initial onset with kidney damage,respiratory tract infection,platelet count,C-reactive protein and immunoglobulin A were the independent prognostic factors of HSP children(all P<0.05).Recurrent rash,respiratory tract infection,platelet count,C-reactive protein and immunoglobulin A had predictive values for poor prognosis of HSP children(all P<0.05).Conclusion:Recurrent rash,initial onset with renal damage,respiratory tract infection,platelet count,C-reactive protein and immunoglobulin A are the independent prognostic factors of HSP children.In addition to the indicator of initial onset with kidney damage,the other indicators have certain predictive value for poor prognosis of HSP children.

关 键 词：过敏性紫癜 儿童 影响因素 预后 预测价值 

分 类 号：R725.5[医药卫生—儿科]