Th1/Th2细胞因子在早产儿呼吸窘迫综合征发病中的研究进展  

Research Progress on the Th1/Th2 Cytokines in the Pathogenesis of Respiratory Distress Syndrome in Premature Infants

作　　者：杨小兰 谢美玲 廖晓兰 刘李 刘燕茹 YANG Xiaolan;XIE Meiling;LIAO Xiaolan;LIU Li;LIU Yanru(Department of Pediatrics,Bazhong Hospital of Traditional Chinese Medicine/People's Hospital of Bazhou District,Bazhong,Sichuan 636000,China;Department of Pediatrics,People's Hospital of Tongchuan District,Dazhou,Sichuan 635099,China;Department of Pediatrics,Chengdu Women and Children's Center Hospital,Chengdu 610000,China)

机构地区：[1]巴中市中医医院(巴州区人民医院)儿科,四川巴中636000 [2]达州市通川区人民医院儿科,四川达州635099 [3]成都市妇女儿童中心医院儿科,成都610000

出　　处：《临床误诊误治》2023年第12期146-149,154,共5页Clinical Misdiagnosis & Mistherapy

基　　金：四川省卫生和计划生育委员会科研课题普及应用项目(18PJ049)。

摘　　要：呼吸窘迫综合征(RDS)好发于早产儿,发病主要与Th1/Th2细胞因子失衡有关,以Th1型细胞因子占优势地位,但Th1/Th2细胞因子失衡参与RDS发生发展的具体机制尚未明确,所以明确RDS的发病机制,采取合理有效的治疗措施是降低早产RDS患儿病死率的关键。故本文通过查阅国内外相关研究资料,着重阐述Th1/Th2细胞因子在早产RDS患儿中的表达及其作用机制,以期为本病的治疗提供新思路。Respiratory distress syndrome(RDS)often strike premature infants,and its pathogenesis is mainly related to Th1/Th2 cytokine imbalance,especially the predominant Th1 cytokine.However,the specific mechanism of Th1/Th2 cytokine imbalance participating in the occurrence and development of RDS has not yet been well understood.Clarifying the pathogenesis of RDS and taking reasonable and effective treatment measures is the key to reducing the mortality of premature children with RDS.Therefore,by referring to relevant research data at home and abroad,this study focused on the expression of Th1/Th2 cytokines in premature children with RDS and its mechanism of action,in order to provide new ideas for the treatment of this disease.

关 键 词：呼吸窘迫综合征 婴儿 早产 TH1细胞因子 肿瘤坏死因子-α TH2细胞因子 白细胞介素-4 肺表面活性物质 综述 

分 类 号：R722.12[医药卫生—儿科]