利培酮和喹硫平治疗精神分裂症临床疗效比较  

Comparison of Clinical Efficacy Between Risperidone and Quetiapine in the Treatment of Schizophrenia

作　　者：朱剑荣 方向明 乐嫣 ZHU Jianrong;FANG Xiangming;LE Yan(Wuhan Special Care Hospital,Wuhan,Hubei,China 430023)

机构地区：[1]湖北省武汉市优抚医院,湖北武汉430023

出　　处：《中国药业》2024年第5期97-101,共5页China Pharmaceuticals

基　　金：职业危害识别与控制湖北省重点实验室开放基金项目[OHIC2021Z04]。

摘　　要：目的比较利培酮和喹硫平治疗精神分裂症的临床疗效,以及对患者临床症状、认知功能及睡眠的影响。方法选取医院2018年12月至2021年12月收治的精神分裂症患者120例,根据治疗方法的不同分为利培酮组(52例)和喹硫平组(68例),两组患者分别予利培酮和喹硫平,均治疗1个月。结果治疗后,两组患者的血清磷髓脂碱性蛋白(MBP)水平均显著降低(P<0.05),胶质细胞源性神经营养因子(GDNF)水平均显著升高(P<0.05),且喹硫平组均显著优于利培酮组(P<0.05);两组患者的蒙特利尔认知评估量表(MoCA)评分均显著升高(P<0.05),且喹硫平组显著高于利培酮组(P<0.05);两组患者的匹兹堡睡眠质量指数量表(PSQI)的睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物、日间功能障碍评分及总分均显著降低(P<0.05),且喹硫平组均显著低于利培酮组(P<0.05);两组患者的阳性和阴性症状量表(PANSS)的阳性症状、阴性症状、一般精神病理评分和总分均显著降低(P<0.05),但组间无显著差异(P>0.05)。喹硫平组和利培酮组的总有效率和不良反应发生率相当(92.65%比88.46%,5.88%比11.54%,P>0.05)。结论利培酮和喹硫平治疗精神分裂症的临床疗效相当,均能有效改善患者的PANSS评分,但喹硫平对患者的血清MBP和GDNF水平、认知功能及睡眠质量的改善效果较利培酮更佳。Objective To compare the clinical efficacy between risperidone and quetiapine in the treatment of schizophrenia,and their effect on clinical symptoms,cognitive function,and sleep in patients.Methods A total of 120 patients with schizophrenia admitted to the hospital from December 2018 to December 2021 were selected and divided into the risperidone group(52 cases)and the quetiapine group(68 cases)according to different treatment methods.The patients in the risperidone group were treated with risperidone,while the patients in the quetiapine group were treated with quetiapine.Both groups were treated for one month.Results After treatment,the levels of serum myelin basic protein(MBP)in the two groups significantly decreased(P<0.05),while the levels of glial cell-derived neurotrophic factor(GDNF)in the two groups significantly increased(P<0.05),and those in the quetiapine group were significantly better than those in the risperidone group(P<0.05);the Montreal Cognitive Assessment Scale(MoCA)score in the two groups significantly increased(P<0.05),and that in the quetiapine group was significantly higher than that in the risperidone group(P<0.05);the total Pittsburgh Sleep Quality Index(PSQI)score and each factor score of subjective sleep quality,sleep latency,sleep duration,habitual sleep efficiency,sleep disturbance,used sleep medication,daytime dysfunction in the two groups significantly decreased(P<0.05),and those in the quetiapine group were significantly lower than those in the risperidone group(P<0.05);the positive and negative symptoms,general psychopathological score,and total Positive and Negative Symptom Scale(PANSS)score in the two groups significantly decreased(P<0.05),but there was no significant difference between the two groups(P>0.05).The total effective rate and incidence of adverse reactions were comparable between the quetiapine group and the risperidone group(92.65%vs.88.46%,5.88%vs.11.54%,P>0.05).Conclusion The clinical efficacy of risperidone and quetiapine in the treatment of schizophrenia is com

关 键 词：精神分裂症 利培酮 喹硫平 阳性和阴性症状量表 睡眠质量 认知功能 

分 类 号：R969.4[医药卫生—药理学] R971.41[医药卫生—药学]