性激素与胰岛素对多囊卵巢综合征诊断价值分析  

Analysis of the Diagnostic Value of Sex Hormones and Insulin in Polycystic Ovary Syndrome

作　　者：陆金芬 LU Jinfen(Jingjiang Hospital of Traditional Chinese Medicine,Jingjiang 214500,China)

机构地区：[1]靖江市中医院,靖江214500

出　　处：《中国医药指南》2024年第7期52-54,共3页Guide of China Medicine

摘　　要：目的 探讨多囊卵巢综合征诊断中,性激素水平与胰岛素抵抗数值的价值。方法 收集2022年6月至2023年6月本院妇科门诊接诊的80例多囊卵巢综合征患者病例资料,按有无胰岛素抵抗分为IR组49例和NIR组31例。比较两组空腹及75 g糖负荷2 h的血糖、胰岛素水平、稳态模型指数以及早卵泡期空腹性激素(卵泡刺激素、黄体生成素、催乳素、睾酮、雌二醇和黄体生成素/卵泡刺激素比值),分析性激素与稳态模型指数的相关性以及性激素与胰岛素的诊断价值。结果 两组空腹葡萄糖、空腹胰岛素、稳态模型指数、2 h葡萄糖、2 h血清胰岛素、黄体生成素、催乳素、雌二醇、睾酮组间均有差异(P <0.05)。睾酮与稳态模型指数存在正相关(P <0.05),雌二醇与稳态模型指数负相关(P <0.05)。ROC曲线分析显示,血清催乳素、雌二醇、睾酮和胰岛素曲线下面积(AUC)分别为0.655、0.695、0.802、0.752,联合检测AUC为0.824,联合测定AUC明显高于单个指标。血清催乳素、雌二醇、睾酮和胰岛素联合评估多囊卵巢综合征的结果与临床诊断的符合程度为0.758,对多囊卵巢综合征的敏感度为86.75%,特异度为85.45%,准确度为86.82%,阳性和阴性分别为85.12%和86.58%。结论 性激素水平与胰岛素抵抗数值可作为多囊卵巢综合征的诊断指标。Objective To explore the value of sex hormone levels and insulin resistance values in the diagnosis of polycystic ovary syndrome.Methods A total of 80 patients with polycystic ovary syndrome admitted to the gynecology outpatient department of our hospital from June 2022to June 2023 were collected.They were divided into an IR group of 49 cases and a NIR group of 31 cases based on insulin resistance.Compare the blood glucose,insulin levels,steady-state model index,and early follicular phase fasting sex hormones [follicle stimulating hormone,luteinizing hormone,prolactin,testosterone,estradiol,and luteinizing hormone/follicle stimulating hormone values] between two groups of fasting and 75 g glucose load for 2 hours,analyze the correlation between sex hormones and steady-state model index,and the diagnostic value of sex hormones versus insulin.Results There were differences in fasting glucose,fasting insulin,steady-state model index,2-hour glucose,2-hour serum insulin,luteinizing hormone,prolactin,estradiol,and testosterone between the two groups(P<0.05).Testosterone is positively correlated with the steadystate model index(P<0.05),while estradiol is negatively positively correlated with the steady-state model index(P<0.05).Using ROC curve analysis,the area under the curve(AUC) of serum prolactin,estradiol,testosterone,and insulin were 0.655,0.695,0.802,and 0.752,respectively.The AUC of the combined test was 0.824,and the AUC of the combined test was significantly higher than that of a single indicator.The consistency between the combined evaluation of serum prolactin,estradiol,testosterone,and insulin for polycystic ovary syndrome and clinical diagnosis is 0.758,which is very high.The sensitivity to polycystic ovary syndrome is 86.75%,specificity is 85.45%,accuracy is 86.82%,positive and negative are 85.12% and 86.58%,respectively.Conclusions Sex hormone levels and insulin resistance values can serve as diagnostic indicators for polycystic ovary syndrome.

关 键 词：多囊卵巢综合征 胰岛素抵抗 性激素水平 诊断价值 相关性 

分 类 号：R711.75[医药卫生—妇产科学]