稳心颗粒联合盐酸决奈达隆片对阵发性房颤患者氧化应激、心肌纤维化和外周血单核细胞Cx40、Cx43的影响  

Effects of Wenxin Granule Combined with Dronedarone Hydrochloride Tablets on Oxidative Stress,Myocardial Fibrosis and Peripheral Blood Mononuclear Cell Cx40 and Cx43 in Patients with Paroxysmal Atrial Fibrillation

作　　者：龙骁 陈然[1] 黄玉艳 汤长春 李亮[1] LONG Xiao;CHEN Ran;HUANG Yu-yan;TANG Chang-chun;LI Liang(Department of Internal Medicine-Cardiovascular,Changsha Central Hospital Affiliated to South China University,Changsha,Hunan,410000,China)

机构地区：[1]南华大学附属长沙中心医院心内科,湖南长沙410000

出　　处：《现代生物医学进展》2024年第1期140-143,共4页Progress in Modern Biomedicine

基　　金：湖南省卫生健康委科研计划项目(20201904)。

摘　　要：目的:观察稳心颗粒联合盐酸决奈达隆片对阵发性房颤(PAF)患者氧化应激、心肌纤维化和外周血单核细胞缝隙连接蛋白40(Cx40)信使核糖核酸(mRNA)、缝隙连接蛋白43(Cx43)mRNA的影响。方法:选取2020年3月~2022年12月期间在我院治疗的79例PAF患者为研究对象。按照随机数字表法将患者分为对照组(39例,盐酸决奈达隆片治疗)和研究组(40例,稳心颗粒联合盐酸决奈达隆片治疗)。对比两组房颤(AF)发作次数、静息心率、AF持续时间、氧化应激指标、心肌纤维化指标和外周血单核细胞Cx40mRNA、Cx43mRNA的变化情况。结果:与对照组治疗12周后相比,研究组的AF发作次数更少,静息心率更低,AF持续时间更短,丙二醛(MDA)、Ⅲ型前胶原氨基末端肽(PⅢNP)、基质金属蛋白酶-2(MMP-2)、外周血单核细胞Cx40mRNA、Cx43mRNA更低,超氧化物歧化酶(SOD)更高(P<0.05)。结论:稳心颗粒联合盐酸决奈达隆片治疗PAF患者,可有效改善患者的临床症状,减轻患者的氧化应激、心肌纤维化损伤,调节外周血单核细胞Cx40mRNA、Cx43mRNA水平。Objective:To observe the effects of wenxin granule combined with dronedarone hydrochloride tablets on oxidative stress,myocardial fibrosis and peripheral blood mononuclear cell connexin 40(Cx40)messenger RNA(mRNA)and connexin 43(Cx43)mRNA in patients with paroxysmal atrial fibrillation(PAF).Methods:79 PAF patients who were treated in our hospital from March 2020 to December 2022 were selected as study subjects.Patients were divided into control group(39 cases,treated with dronedarone hydrochloride tablets)and study group(40 cases,treated with wenxin granule combined with dronedarone hydrochloride tablets)according to the random number table method.The frequency of atrial fibrillation(AF),resting heart rate,AF duration,oxidative stress index,myocardial fibrosis index and the changes of peripheral blood mononuclear cell Cx40mRNA and Cx43mRNA were compared between two groups.Results:Compared with the control group at 12 weeks after treatment,the study group had fewer AF attacks,lower resting heart rate,shorter AF duration,lower malondialdehyde(MDA),procollagen type III amino terminal peptide(PⅢNP),matrix metalloproteinase-2(MMP-2),peripheral blood,monocyte Cx40mRNA,Cx43mRNA,and higher superoxide dismutase(SOD)(P<0.05).Conclusion:Wenxin granule combined with dronedarone hydrochloride tablets in the treatment of PAF patients can effectively improve the clinical symptoms of patients,reduce the oxidative stress and myocardial fibrosis injury of patients,and regulate the levels of peripheral blood mononuclear cell Cx40mRNA and Cx43mRNA.

关 键 词：稳心颗粒 盐酸决奈达隆片 阵发性房颤 氧化应激 心肌纤维化 CX40 CX43 

分 类 号：R541.75[医药卫生—心血管疾病]