基于网络药理学探讨柴芩温胆汤治疗糖尿病胃轻瘫的作用机制  

The Mechanism of Chaiqin Wendan Decoction in the Treatment of Diabetic Gastroparesis Based on Network Pharmacology

作　　者：蒋丽娜 罗倩 刘琴 刘罗苗 吴源陶 周月红[3] JIANG Lina;LUO Qian;LIU Qin;LIU Luomiao;WU Yuantao;ZHOU Yuehong(The First Clinical School of Traditional Chinese Medicine,Hunan University of Traditional Chinese Medicine,Changsha 410007,Hunan,China;The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410007,Hunan,China;Liuyang City Hospital of Traditional Chinese Medicine,Liuyang 410300,Hunan,China)

机构地区：[1]湖南中医药大学第一中医临床学院,湖南长沙410007 [2]湖南中医药大学第一附属医院,湖南长沙410007 [3]浏阳市中医医院,湖南浏阳410300

出　　处：《中国药物滥用防治杂志》2024年第1期48-51,共4页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：湖南省中医药管理局项目(编号:D2022101)。

摘　　要：目的:运用网络药理学方法探析柴芩温胆汤(CQWWD)治疗糖尿病胃轻瘫(DGP)的潜在作用机制。方法:利用中药系统药理学数据库和分析平台和本草组鉴获取CQWWD的主要活性成分和作用靶点,在GeneCards、OMIM、DisGeNET、Drug Bank、PharmGKB、TTD数据库中预测DGP靶点,将药物作用靶点与DGP预测靶点取交集靶点,运用STRING数据库和Cytoscape3.7.2软件构建PPI网络,运用DAVID数据库行GO功能富集和KEGG通路富集分析。结果:筛选出CQWWD中的263个作用靶点,DGP疾病靶点共1439个,交集靶点61个,GO富集分析得到224个条目,涉及224个生物过程、18个细胞成分、38个分子功能,KEGG通路富集包含111条目。结论:本研究初步揭示CQWWD治疗DGP是多成分、多靶点、多通路的过程,为后续研究提供了支持。Objective:To explore the potential mechanism of Chaiqin Wendan Decoction(CQWWD)in the treatment of diabetic gastroparesis(DGP)by network pharmacology.Methods:The main active components and targets of CQWWD were obtained by using the traditional Chinese medicine system pharmacology database and analysis platform and herbal group identification.The DGP targets were predicted in GeneCards,OMIM,DisGeNET,Drug Bank,PharmGKB and TTD databases,and the drug targets were intersected with the DGP predicted targets.The PPI network was constructed by STRING database and Cytoscape 3.7.2 software,and the GO function enrichment and KEGG pathway enrichment analysis were performed by DAVID database.Results:A total of 263 targets were identified in the screening of Chaiqin Wendan Decoction.Among these targets,1439 were associated with DGP disease,and 61 were found to be intersecting targets.Through GO enrichment analysis,224 items were obtained,encompassing 224 biological processes,18 cellular components,and 38 molecular functions.Additionally,KEGG pathway enrichment analysis revealed 111 items.Conclusion:This study initially demonstrated that the treatment of DGP with CQWWD involves multiple components,targets,and pathways,thereby providing a solid foundation for further research in this area.

关 键 词：柴芩温胆汤 糖尿病胃轻瘫 网络药理学 作用机制 

分 类 号：R285[医药卫生—中药学]