复方福尔可定联合孟鲁司特钠治疗小儿急性支气管炎的临床效果  

Clinical effect of compound pholcodine combined with montelukast sodium in the treatment of acute bronchitis in children

作　　者：许冲 李宁 李翔 XU Chong;LI Ning;LI Xiang(Pharmacy Department,Traditional Chinese Medicine Hospital of Pingdingshan,Pingdingshan 467000,China)

机构地区：[1]平顶山市中医医院药学部,河南平顶山467000

出　　处：《临床医学研究与实践》2024年第7期89-92,共4页Clinical Research and Practice

摘　　要：目的探究复方福尔可定联合孟鲁司特钠治疗小儿急性支气管炎的临床效果。方法选择2020年12月至2022年12月我院收治的106例急性支气管炎患儿作为研究对象,采用随机数字表法将其分为对照组和联合组,各53例。对照组采用孟鲁司特钠治疗,联合组在对照组基础上加用复方福尔可定治疗。比较两组的治疗效果。结果联合组的治疗总有效率为94.34%,显著高于对照组的81.13%(P<0.05)。联合组的体温恢复、咳嗽消失、咳痰消失、肺部体征消失时间及住院时间均短于对照组(P<0.05)。治疗后,联合组的潮气量(V-T)、达峰时间比(TPEF/TE)高于对照组,呼吸频率(RR)、呼吸时间比(Ti/Te)低于对照组(P<0.05)。治疗后,联合组的α1-酸性糖蛋白(α1-AG)、结合珠蛋白(HP)、超敏C反应蛋白(hs-CRP)、半胱氨酰白三烯(CysLTs)、单核细胞趋化蛋白-4(MCP-4)、降钙素原(PCT)水平低于对照组(P<0.05)。结论复方福尔可定联合孟鲁司特钠治疗小儿急性支气管炎的效果显著,可加快病情恢复,减轻气道炎症,改善肺功能。Objective To explore the clinical effect of compound pholcodine combined with montelukast sodium in the treatment of acute bronchitis in children.Methods A total of 106 children with acute bronchitis admitted in our hospital from December 2020 to December 2022 were selected as the research objects,and the children were divided into control group and combined group by random number table method,with 53 cases in each group.The control group was treated with montelukast sodium,and the combined group was treated with compound pholcodine on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the combined group was 94.34%,which was significantly higher than 81.13%in the control group(P<0.05).The time of body temperature recovery,cough disappearance,expectoration disappearance,lung sign disappearance and hospitalization time in the combined group were shorter than those in the control group(P<0.05).After treatment,the tidal volume(V-T)and ratio of time to peak tidal expiratory flow and total expiratory time(TPEF/TE)in the combined group were higher than those in the control group,respiratory rate(RR)and inspiratory time/expiratory time(Ti/Te)were lower than those in the control group(P<0.05).After treatment,the levels ofα1-acid glycoprotein(α1-AG),haptoglobin(HP),hypersensitive C-reactive protein(hs-CRP),cysteinyl leukotrienes(CysLTs),monocyte chemotactic protein-4(MCP-4)and procalcitonin(PCT)in the combined group were lower than those in the control group(P<0.05).Conclusion Compound pholcodine combined with montelukast sodium has a significant effect in the treatment of acute bronchitis in children,which can accelerate the recovery of the disease,reduce airway inflammation and improve lung function.

关 键 词：小儿 急性支气管炎 复方福尔可定 孟鲁司特钠 急性时相反应蛋白 

分 类 号：R725.6[医药卫生—儿科]