氨茶碱与喷托维林应用于老年睡眠呼吸暂停综合征的有效性及不良反应研究  

Study on the Efficacy and Adverse Reactions of Aminophylline and Pentovorin in Elderly Patients with Sleep Apnea Syndrome

作　　者：卢桂清 纪梅芳 LU Guiqing;JI Meifang(Department of Pharmacy,The First Affiliated Hospital of Xiamen University,Xiamen 361000,China)

机构地区：[1]福建省厦门大学附属第一医院制剂科,厦门361000

出　　处：《世界睡眠医学杂志》2023年第11期2614-2616,共3页World Journal of Sleep Medicine

摘　　要：目的:观察临床上对老年睡眠呼吸暂停综合征患者展开治疗,选择分别施用氨茶碱、喷托维林治疗措施干预的效果。方法:选取2022年1月至2022年12月福建省厦门大学附属第一医院制剂科收治的老年睡眠呼吸暂停综合征患者60例作为研究对象,按照随机数字表法随机分为观察组和对照组,每组30例。观察组患者实施喷托维林治疗,对照组患者实施氨茶碱治疗。对2组患者的治疗总有效率、不良反应发生率、睡眠呼吸障碍维持时间进行比较。结果:治疗后,观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05);观察组睡眠呼吸障碍维持时间低于对照组,差异有统计学意义(P<0.05)。结论:喷托维林治疗临床老年睡眠呼吸暂停综合征患者,所得干预的评估结果更好。治疗后,患者的症状得到较好的改善,且不良反应出现情况有所减少,睡眠呼吸障碍维持时间缩短,值得临床推广应用。Objective:To observe the therapeutic effects of aminophylline and pentovorin on elderly patients with sleep apnea syndrome in clinical practice.Methods:The research subjects of this study in our hospital were 60 elderly patients with sleep apnea syndrome who received treatment from January 2022 to December 2022.They were randomly selected and divided into an observation group and a control group with 30 cases each.The observation group of participants in this study received treatment with pentovorin,while the control group received treatment with aminophylline.After the intervention,compare the total effective rate of treatment,the probability of adverse reactions,and the duration of sleep breathing disorders between the subjects.Results:After the treatment work was carried out,the total effective rate of the research value treatment was higher in the observation group than in the control group,the difference was statistically significant(P<0.05);the probability of adverse reactions in the obtained research values and the evaluation results of the intervention subjects in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05);the maintenance time of sleep apnea in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The evaluation results of the intervention are better when Pentavirin treatment is applied to the clinical treatment of elderly patients with sleep apnea syndrome.After the implementation of treatment,the patient′s symptoms have been improved significantly,and the occurrence of adverse reactions has been reduced.The maintenance time of sleep breathing disorders has been shortened,which is worthy of clinical application and promotion.

关 键 词：氨茶碱 喷托维林 老年睡眠呼吸暂停综合征 有效性 不良反应 

分 类 号：R56[医药卫生—呼吸系统] R338.63[医药卫生—内科学]