盐酸曲唑酮联合艾司唑仑片治疗老年失眠患者PSQI、TST、REML评分的变化  

Changes in PSQI,TST,and REML Scores in Elderly Insomnia Patients Treatedwith Trazodone Hydrochloride Combined with Estazolam Tablets

作　　者：叶敏 YE Min(Pharmacy Department of Sanyuan District Second Hospital in Sanming,Sanming 365000,China)

机构地区：[1]三明市三元区第二医院药剂科,三明365000

出　　处：《世界睡眠医学杂志》2023年第12期2781-2783,共3页World Journal of Sleep Medicine

摘　　要：目的:观察盐酸曲唑酮联合艾司唑仑片治疗老年失眠患者匹兹堡睡眠质量指数(PSQI)、总睡眠时间(TST)、快速眼动睡眠潜伏期(REML)评分的变化。方法:选取2022年6月至2023年3月三明市三元区第二医院收治的老年失眠患者72例作为研究对象,按照双盲法分为对照组和观察组,每组36例。对照组采用单一艾司唑仑片治疗,观察组采用盐酸曲唑酮联合艾司唑仑片治疗,比较2组疗效。结果:观察组治疗总有效率更高;治疗后,观察组PSQI各条目评分和总分低于对照组,护理满意度各维度评分均高于对照组,TST、REML高于对照组,差异均有统计学意义(均P<0.05)。组间不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:对老年失眠患者实施盐酸曲唑酮联合艾司唑仑片治疗,疗效显著,可有效改善患者睡眠质量,安全性良好。Objective:To observe the changes in Pittsburgh Sleep Quality Index(PSQI),Total Sleep Time(TST),and Rapid Eye Movement Sleep Latency(REML)scores of elderly insomnia patients treated with trazodone hydrochloride combined with estazolam tablets.Methods:A total of 72 elderly insomnia patients treated in our outpatient department from June 2022 to March 2023 were selected as the study subjects.They were divided into a control group(n=36)and an observation group(n=36)using a double blind method.The control group was treated with a single estazolam tablet,while the observation group was treated with trazodone hydrochloride combined with estazolam tablets.The therapeutic effects of the two groups were compared.Results:The total effective rate was higher in the observation group.After treatment,the scores of PSQI items and total scores in the observation group were lower than those in the control group,the scores of nursing satisfaction dimensions were higher than those in the control group,and TST and REML were higher than those in the control group,with statistical significance(P s<0.05).There was no significant difference in the total incidence of adverse reactions between groups(P>0.05).Conclusion:The treatment of elderly insomnia patients with trazodone hydrochloride combined with estazolam tablets has a significant therapeutic effect,can effectively improve the patient′s sleep quality,and has good safety.

关 键 词：盐酸曲唑酮 艾司唑仑片 老年失眠 睡眠质量 总睡眠时间 

分 类 号：R338.63[医药卫生—人体生理学] R256.23[医药卫生—基础医学]