中国内地首例本土感染猴痘病例流行病学和临床特征分析  

Epidemiological and clinical characteristics of the first local mpox case in the Chinese mainland

作　　者：张鼎言 李夫 李利伟[3] 林杨 张芳蕾[1] 黄晨铭 张烨 吴钶[1] 韩柏慧[1] 窦相峰[2] 孟玲玉 齐啸[1] Zhang Dingyan;Li Fu;Li Liwei;Lin Yang;Zhang Fanglei;Huang Chenming;Zhang Ye;Wu Ke;Han Baihui;Dou Xiangfeng;Meng Lingyu;Qi Xiao(Chaoyang District Center for Diseases Prevention and Control,Beijing 100021,China;Beijing Municipal Center for Diseases Prevention and Control,Beijing 100013,China;Beijing Chuiyangliu Hospital,Beijing 100022,China;Xicheng District Center for Diseases Prevention and Control,Beijing 100120,China)

机构地区：[1]北京市朝阳区疾病预防控制中心,北京100021 [2]北京市疾病预防控制中心,北京100013 [3]北京市垂杨柳医院,北京100022 [4]北京市西城区疾病预防控制中心,北京100120

出　　处：《疾病监测》2024年第1期16-19,共4页Disease Surveillance

摘　　要：目的描述中国内地首例本土感染猴痘病例的流行病学特征及临床表现,为今后猴痘的防控工作提供科学支撑。方法对病例开展流行病学调查,了解其发病情况及高风险暴露史,确定其感染来源。根据方案对其密切接触者(密接)开展管理,追踪其发病情况。通过实时荧光定量PCR法对采集的人员及环境样本进行检测。结果2023年5月26日,病例出现皮疹、淋巴结肿大,27日出现发热,31日经检测咽拭子、皮疹涂抹、血液样本猴痘病毒核酸阳性,6月1日前往定点医院隔离治疗,6月12日出院。病例发病前21 d内,因与1例入境猴痘感染者发生两次性接触导致感染。在该病例发病后,1例与其发生性关系的密接出现续发感染,其发病后到访的公共场所环境样本猴痘病毒核酸均为阴性,未发现其他接触者出现感染。结论此病例为我国内地首例猴痘本土感染确诊病例,感染来源为输入性猴痘病例,造成1例性接触密接感染。当前亟需提升猴痘的发现及诊断能力,及早针对男同性行为人群进行干预以降低感染风险,猴痘向一般人群扩散风险相对较低。Objective To describe the epidemiological characteristics and clinical manifestations of the first local mpox case in the Chinese mainland and provide evidence for the prevention and control of mpox.Methods An epidemiological investigation was conducted to understand the case's onset,high-risk exposure and identify the source of infection.Real-time polymerase chain reaction was performed to detect case and environmental samples.Results The case developed rash and inguinal lymphadenopathy on May 26,2023 and had a fever on May 27.On May 31,case samples of skin rash swab,oropharyngeal swab,and blood were tested positive for mpox virus(MPXV).The case was transferred to a sentinel hospital for isolation treatment on June 1 and discharged on June 12.Epidemiological investigation revealed that the case had sexual exposure for 2 times to an imported mpox case within 21 days,and a close contact with whom the case had sex was also infected.Environment samples from public places visited by the case after onset were tested negative for MPXV,and no other contacts were found to be infected.Conclusion The case was the first local mpox case in the Chinese mainland,and the infection source was an imported mpox case.There is an urgent need to improve the detection and diagnosis of mpox and conduct intervention as early as possible to reduce the infection risk in men who have sex with men.The risk of the spread of mpox to general population is relatively low.

关 键 词：猴痘 男同性行为者 流行病学调查 

分 类 号：R211[医药卫生—中医学] R511