骨质疏松症易感基因多态性在广西壮族人群中的研究进展  

Progress in Gene Polymorphisms Associated With Osteoporosis Susceptibility in Zhuang Ethnic Group in Guangxi

作　　者：黄思雨 叶广彬 何钰佳 宾晓芸[1] 周敏 黄秀峰[1] HUANG Siyu;YE Guangbin;HE Yujia;BIN Xiaoyun;ZHOU Min;HUANG Xiufeng(School of Basic Medical Sciences,YouJiang Medical University for Nationalities,Baise,Guangxi 533000,China;School of Public Health and Management,YouJiang Medical University for Nationalities,Baise,Guangxi 533000,China)

机构地区：[1]右江民族医学院基础医学院,广西百色533000 [2]右江民族医学院公共卫生与管理学院,广西百色533000

出　　处：《中国医学科学院学报》2024年第1期82-87,共6页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(32060208);广西自然科学基金(2017GXNSFAA198101);广西高校中青年教师基础能力提升项目(2022KY0541)。

摘　　要：本文旨在对广西壮族群体中骨质疏松症(OP)易感基因多态性的研究进行系统总结和阐述,包括维生素D受体、雌激素受体、降钙素受体、脂联素基因及其他与OP相关的基因多态性。在壮族与其他不同种族或民族间,对基因型和等位基因分布频率进行差异性比较分析,以此厘清壮族现有的可能与OP相关的基因,以及与壮族OP相关的基因多态性,为少数民族OP易感基因的研究提供一个代表性的解决方案。The purpose of this paper is to systematically summarize the gene polymorphisms associated with osteoporosis(OP)susceptibility in Zhuang ethnic group in Guangxi.These genes mainly encode vitamin D receptor,estrogen receptor,calcitonin receptor,and adiponectin.The genotype and allele distribution frequency were compared between Zhuang ethnic group and other ethnic groups,which can clarify the existing genes and the potential gene polymorphism associated with OP in Zhuang ethnic group.The findings provide a representative solution for the subsequent research on the genes associated with OP susceptibility in ethnic minorities.

关 键 词：少数民族 骨质疏松症 基因多态性 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]