酒精使用障碍患者短期戒断治疗灰质体积的形态学研究  

Morphological study on gray matter volume changes of short-term withdrawal therapy in patients with alcohol use disorder

作　　者：杨硕 姚文君[2] YANG Shuo;YAO Wenjun(Department of Radiology,the Affiliated Psychological Hospital of Anhui Medical University,Hefei 230022,China;Department of Radiology,the Second Hospital of Anhui Medical University,Hefei 230601,China)

机构地区：[1]安徽医科大学附属心理医院放射科,安徽合肥230022 [2]安徽医科大学第二附属医院放射科,安徽合肥230601

出　　处：《实用放射学杂志》2024年第1期15-18,26,共5页Journal of Practical Radiology

摘　　要：目的探讨酒精使用障碍(AUD)患者短期戒断治疗后大脑结构的变化。方法纳入男性AUD患者28例,于入组时及标准化治疗2~3周后分别行头颅MRI扫描,利用基于体素的形态学测量(VBM)技术测量治疗前后脑组织总体积及灰质、白质、脑脊液体积进行比较,后根据自动解剖标记(AAL)模板分割测量出全脑各脑区灰质体积并进行统计学分析。结果与基线数据相比,标准化治疗2~3周后,脑组织中灰质体积显著增加,脑脊液体积显著减少;相较于治疗前,左侧大脑半球灰质体积增加的脑区分布在内侧和旁扣带回、中央沟盖、楔前叶及脑岛,右侧大脑半球灰质体积增加的脑区分布在前扣带回、旁扣带回、中央沟盖、杏仁核、颞上回、颞中回、颞横回、楔前叶、中央后回、缘上回、距状裂周围皮层及脑岛。结论AUD患者短期戒断治疗后灰质体积得到一定程度的增加,尤其是前额叶。Objective To explore the changes in brain structure after short-term withdrawal therapy in patients with alcohol use disorder(AUD).Methods A total of 28 male patients with AUD were included,and brain MRI scans were performed at the time of enrollment and 2-3 weeks after standardized treatment.The total volume of brain tissue,gray matter,white matter and cerebrospinal fluid volume before and after treatment were measured by voxel-based morphometry(VBM)technology,and the gray matter volume of each brain region of the whole brain was measured and statistically analyzed according to the automated anatomical labeling(AAL)template.Results Compared with the baseline data,after 2-3 weeks of standardized treatment,the volume of gray matter in brain tissue increased significantly,and the volume of cerebrospinal fluid decreased significantly.Compared with before treatment,the brain regions with increased gray matter volume in the left hemisphere were distributed in the medial and paracingulate gyrus,central sulcus cover,anterior wedge lobe and insula,and the brain regions with increased gray matter volume in the right hemisphere were distributed in the anterior cingulate gyrus,paracingulate gyrus,central sulcus cover,amygdala,superior temporal gyrus,middle temporal gyrus,transverse temporal gyrus,anterior cuneiformus,posterior central gyrus,superior marginal gyrus,peritaloid cortex and insula.Conclusion Patients with AUD experience some increases in gray matter volume,especially in the prefrontal lobe,after short-term withdrawal therapy.

关 键 词：磁共振成像 酒精使用障碍 基于体素的形态学测量 灰质体积 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.62[医药卫生—诊断学]