定量MRI技术在早期椎间盘退变诊断中的应用  

The application of quantitative MRI in the diagnosis of early intervertebral disc degeneration

作　　者：秦睿婧 刘九临 殷慧佳 张梦 李玉侠[1] 任继鹏[1] 韩东明[1] QIN Ruijing;LIU Jiulin;YIN Huijia;ZHANG Meng;LI Yuxia;REN Jipeng;HAN Dongming(Department of Magnetic Resonance,the First Affiliated Hospital of Xinziang Medical University,Weihui,He'nan Province 453100,China)

机构地区：[1]新乡医学院第一附属医院磁共振科,河南卫辉453100

出　　处：《实用放射学杂志》2024年第1期79-83,共5页Journal of Practical Radiology

基　　金：医学与健康事业研究发展基金项目-伦琴影像科研专项(HN-20201017-002)。

摘　　要：目的评估定量MRI技术T2 mapping及mDixonQuant在早期椎间盘退变诊断中的潜在临床价值。方法使用3.0TMR对79例行腰椎MRI检查的患者进行T2WI、T2 mapping、mDixonQuant成像,同时记录患者腰痛情况。统计分析分级为PfirrmannⅠ级和PfirrmannⅡ级的椎间盘(其中Ⅰ级76个,Ⅱ级87个)椎体(V)、髓核(NP)的脂肪分数(FF)值、T2 mapping(map)值的差异。对有意义的参数进行受试者工作特征(ROC)曲线分析。结果V-FF与椎间盘退行性病变呈轻度正相关,NP-FF和NP-map值与病变呈轻度负相关。在2组之间,V-FF(P<0.001)、NP-FF(P=0.005)和NP-map(P<0.001)统计学差异显著;不同节段椎间盘分别比较时,部分测量值存在统计学差异。结论V-FF、NP-FF和NP-map与椎间盘退变存在联系,T2 mapping及mDixonQuant具有潜在的价值,可以定量地评估早期椎间盘退变并帮助诊断。Objective To evaluate the potential clinical value of T_(2) mapping and mDixon Quant in the diagnosis of early intervertebral disc degeneration.Methods A total of 79 volunteers who underwent lumbar MRI examination were enrolled.All subjects were examined for 3.oT MR with T_(2) WI,T_(2),mapping,and mDixon Quant while recording the condition of low back pain.The differences between T,mapping(map)value and fat fraction(FF)values of the vertebral(V)and nucleus pulposus(NP)within the Pfirrmann I and Pfirrmann II intervertebral disc(grade I 76,grade II 87)were statistically analyzed.Receiver operating characteristic(ROC)curve analyses were performed for meaningful parameters.Results V-FF showed a mild positive correlation with degenerative intervertebral disc lesions,and NP-FF and NP-map values showed a mild negative correlation with lesions.There were statistically significant dfferences between the two groups in V-FF(P<0.001),NP-FF(P=0.005),and NP-map(P<0.001).Some measurements had statistically significant differences when different intervertebral disc segments were compared.Conclusion V-FF,NP-FF,and NP-map are associated with intervertebral disc degeneration.T,mapping and mDixon Quant are potentially valuable as diagnostic tools to quantitatively assess early intervertebral disc degeneration and help diagnose.

关 键 词：磁共振成像 T_(2)mapping mDixonQuant 腰椎间盘退行性变 

分 类 号：R445.2[医药卫生—影像医学与核医学] R681.5[医药卫生—诊断学]