中药红花黄色素A对重型颅脑损伤后炎性反应及预后的影响  

Inhibitory effect of safflower yellow pigment A on inflammatory response and prognosis after severe traumatic brain injury

作　　者：黄敏[1] 郭旭东 俞小军 Huang Min;Guo Xudong;Yu Xiaojun(Department of Neurosurgery,Yanshan People’s Hospital(Yanshan Hospital,Second Affiliated Hospital of Nanchang University),Yanshan 334500,China;Department of Neurosurgery,Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou Hui’ai Hospital,Guangzhou 510370,China;Department of Neurosurgery,Affiliated Hospital of Jiujiang University,Jiujiang 332000,China)

机构地区：[1]铅山县人民医院神经外科(南昌大学第二附属医院铅山医院),铅山334500 [2]广州医科大学附属脑科医院神经外科,广州市惠爱医院,广州510370 [3]九江学院附属医院神经外科,九江332000

出　　处：《中华实验外科杂志》2024年第1期145-147,共3页Chinese Journal of Experimental Surgery

基　　金：江西省中医药管理局科技计划一般项目(2021B283)。

摘　　要：目的探讨中药红花黄色素A对重型颅脑损伤后炎性反应及预后的影响。方法60例重型颅脑损伤病例,按照格拉斯哥昏迷评分(GCS)量表进行损伤程度分级,采取红花黄色素A干预治疗,分为干预组和对照组。酶联免疫吸附试验(ELISA)方法检测检测第0、3、6天炎性因子白细胞介素(IL)-6、IL-8和肿瘤坏死因子-α(TNF-α)的表达,格拉斯哥预后评分(GOS)评估治疗前后神经功能变化,分析红花黄色素A对重型颅脑损伤炎症和预后的关系。计量资料符合正态分布,以均数±标准差(±s)表示,采用t检验;计数资料采用频数表示,采用卡方检验。结果与轻度颅脑损伤比较,中度和重度颅脑损伤的IL-6、IL-8、TNF-α表达水平高于轻度颅脑损伤,差异有统计学意义(χ2=5.231,P<0.05)。检测第0、3、6天3个时间点IL-6、IL-8、TNF-α表达水平,结果显示,随着损伤时间延长,两组的炎性因子表达水平逐步升高,差异有统计学意义(χ2=7.421,P<0.05)。与对照组比较,干预组第3天及第6天时间点的IL-6、IL-8、TNF-α表达水平低于对照组,差异有统计学意义(χ2=4.370,P<0.05)。在干预组中,与疗效差比较,疗效好的炎性因子IL-6、IL-8、TNF-α的表达水平低于疗效差组,差异有统计学意义(χ2=8.140,P<0.05)。结论红花黄色素A能抑制促炎因子IL-6、IL-8、TNF-α表达水平,改善重度颅脑损伤预后。Objective To explore the effect of traditional Chinese medicine safflower yellow pigment A on inflammatory response and prognosis after severe traumatic brain injury.Methods A total of 60 cases of severe traumatic brain injury were classified according to the Glasgow Coma Scale(GCS)and treated with safflower yellow A intervention,divided into intervention group and control group.Enzyme linked immunosorbent assay(ELISA)method for detecting inflammatory factors IL-6,IL-8,and TNF-αon days 0,3,and 6.The Glasgow Outcome Scale(GOS)was used to evaluate the changes in neurological function before and after treatment,and to analyze the relationship between safflower yellow pigment A and inflammation and prognosis in severe traumatic brain injury.The measurement data conforms to a normal distribution,represented by mean±standard deviation(±s),and t-test is used;Count data is represented by frequency and chi square test is used.Results Compared with mild traumatic brain injury,the levels of IL-6,IL-8,and TNF-αin moderate and severe traumatic brain injury were higher.The expression level is higher than that of mild traumatic brain injury,and the difference is statistically significant(χ2=5.231,P<0.05).Detect IL-6,IL-8,and TNF-αat three time points d0,d3,and d6.The expression level showed that with the prolongation of injury time,the expression levels of inflammatory factors in the two groups gradually increased,and the difference was statistically significant(χ2=7.421,P<0.05).Compared with the control group,IL-6,IL-8,TNF-αat time points d3 and d6 in the intervention group.The expression level is lower than that of the control group,and the difference is statistically significant(χ2=4.370,P<0.05).In the intervention group,the inflammatory factors IL-6,IL-8,and TNF-αwith better efficacy compared to those with poorer efficacy were found to be effective.The expression level of is lower than that of the treatment group with poor efficacy,and the difference is statistically significant(χ2=8.140,P<0.05).Conclusion Safflo

关 键 词：红花黄色素A 颅脑损伤 炎症 预后 

分 类 号：R651.15[医药卫生—外科学]