旱莲皂苷的溶血活性及构效关系研究  

The Study on Hemolytic Activities and Structure-Activity Relationships of Eclalbasaponins from Eclipta alba

作　　者：刘怀 叶向荣 过七根 张炳火 LIU Huai;YE Xiangrong;GUO Qigen;ZHANG Binghuo(Affiliated Hospital,Jiujiang University,Jiujiang Jiangxi 332001,China;College of Pharmacy and Life Sciences,Jiujiang University,Jiujiang Jiangxi 332005,China)

机构地区：[1]九江学院附属医院,江西九江300201 [2]九江学院药学与生命科学学院,江西九江332005

出　　处：《江西师范大学学报（自然科学版）》2023年第6期594-598,共5页Journal of Jiangxi Normal University(Natural Science Edition)

基　　金：国家自然科学基金(31660096)资助项目。

摘　　要：从旱莲草中分离到7个单体化合物,经波谱数据分析,鉴定为旱莲皂苷eclalbasaponinsⅠ~Ⅵ(缩写为E-Ⅰ~E-Ⅵ)和β-香树素,其中E-Ⅰ~E-Ⅴ有溶血活性,活性强弱依次为E-Ⅱ>E-Ⅳ>E-Ⅴ>E-Ⅰ>E-Ⅲ.构效关系分析结果表明:C-28位的游离羧基对旱莲皂苷的溶血活性强弱至关重要,C-3位葡萄糖基的数量或硫酸酯化对其溶血活性也有影响.Seven compounds are isolated from Eclipta alba.These compounds are identified as eclalbasaponinsⅠ~Ⅵ(abbreviated for E-Ⅰ~E-Ⅵ)andβ-amyrin based on the spectral data.Five compounds,namely E-Ⅰ~E-Ⅴ,show hemolytic activities that the decreasing order is E-Ⅱ>E-Ⅳ>E-Ⅴ>E-Ⅰ>E-Ⅲ.Analysis of structure-activity relationships indicates that free carboxyl at C-28 plays a crucial role in the hemolytic activities of eclalbasaponins.Both the amount and the sulfation of the glucosyl at C-3 also influence the hemolytic activities of eclalbasaponins.

关 键 词：旱莲草 旱莲皂苷 溶血活性 构效关系 

分 类 号：Q946[生物学—植物学]