纤溶酶激活物抑制物1和三磷酸腺苷结合盒转运体B1(C3435T)基因多态性对使用糖皮质激素药物患者股骨头坏死的诊断价值  

Diagnostic Value of Genetic Polymorphisms of Fibrinolytic Activator Inhibitor 1 and Adenosine Triphosphate-bindingCassette Transporter B1 (C3435T) in Patients with Necrosis of the Femoral Head caused by Glucocorticoid Drug

作　　者：刘小玲 梁金冰 蒋粤桂 黄艳萍 Liu Xiaoling;Liang Jinbing;Jiang Yuegui;Huang Yanping(Maoming People's Hospital,Maoming 525000,Guangdong Province,China)

机构地区：[1]茂名市人民医院,广东茂名525000

出　　处：《中外医药研究》2023年第31期145-147,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：茂名市科技计划项目(编号:2021546)。

摘　　要：目的:分析纤溶酶激活物抑制物1(PAI-1)和三磷酸腺苷结合盒转运体B1(ABCB1)(C3435T)基因多态性对使用糖皮质激素药物患者股骨头坏死(ONFH)的诊断价值。方法:选取2019年9月—2022年1月于茂名市人民医院使用糖皮质激素药物治疗的系统性红斑狼疮(SLE)患者61例作为研究对象,将继发ONFH的30例患者作为ONFH组,将同期行基因检测且未发生ONFH的31例患者作为非ONFH组。检测两组患者的PAI-1(4G/5G)和ABCB1(C3435T)的基因多态性。结果:非ONFH组和ONFH组患者的性别、年龄、身体质量指数、受教育程度、居住地、激素起始量、激素使用累积量>10 g、激素冲击以及合并LN等情况比较,差异无统计学意义(P>0.05)。ONFH组PAI-1中4G4G型患者占比高于非ONFH组,5G4G型/5G5G型占比低于非ONFH组,差异有统计学意义(P=0.024);ONFH组ABCB1(C3435T)中CC型患者占比高于非ONFH组,CT型/TT型患者占比低于非ONFH组,差异有统计学意义(P=0.028)。结论:PAI-1和ABCB1(C3435T)分型与使用糖皮质激素药物治疗的SLE患者发生ONFH密切相关。Objective:To analyze the diagnostic value of genetic polymorphisms of fibrinolytic activator inhibitor 1(PAI-1)and adenosine triphosphate-binding cassette transporter B1(ABCB1)(C3435T)in patients with necrosis of the femoral head(ONFH)caused by glucocorticoid drugs.Methods:61 patients with systemic lupus erythematosus(SLE)who were treated with glucocorti⁃coid drugs in Maoming People's Hospital from September 2019 to January 2022 were selected as the study subjects,and 30 out of the total 61 patients suffered from secondary ONFH and dropped into the ONFH group;while other 31 patients,who didn't have ONFH felt into non-ONFH group,and were carried out a genetic test in the study.The genetic polymorphisms of PAI-1(4G/5G)and ABCB1(C3435T)were detected in both groups.Results:Comparison of gender,age,body mass index,education level,place of residence,hormone initiation dose,total hormone dosage>10 g,hormone shock,and combined LN between patients in the non-ONFH group and the ONFH group showed no statistically significant difference(P>0.05).The percentage of patients with 4G4G type of PAI-1 in the ONFH group was higher than that in the non-ONFH group,and the percentage of patients with 5G4G/5G/5G5G type was lower than that in the non-ONFH group.5G5G type accounted for a lower percentage than the non-ONFH group,and the difference was statistically significant(P=0.024);the percentage of patients with CC type in ABCB1(C3435T)in the ON⁃FH group was higher than that in the non-ONFH group,and the percentage of patients with CT type/TT type was lower than that in the non-ONFH group,and the difference was statistically significant(P=0.028).Conclusion:PAI-1 and ABCB1(C3435T)were closely associated with the occurrence of ONFH in SLE patients treated with glucocorticoid drugs.

关 键 词：系统性红斑狼疮 纤溶酶激活物抑制物1 三磷酸腺苷结合盒转运体B1 基因多态性 股骨头坏死 

分 类 号：R68[医药卫生—骨科学]