布地奈德联合沙丁胺醇雾化吸入治疗慢性阻塞性肺疾病的效果观察  

Observation on the Effect of Budesonide Combined with Salbutamol Nebulized Inhalation in the Treatment of Chronic Obstructive Pulmonary Disease

作　　者：肖琦 Xiao Qi(Zunyi First People's Hospital,Zunyi 563000,Guizhou Province,China)

机构地区：[1]遵义市第一人民医院,贵州遵义563000

出　　处：《中外医药研究》2023年第32期66-68,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨布地奈德联合沙丁胺醇雾化吸入治疗慢性阻塞性肺疾病(COPD)的效果。方法:选取2020年2月—2022年12月遵义市第一人民医院收治的COPD患者80例为研究对象,采用随机数表法分为对照组和观察组,各40例。在常规治疗基础上,对照组进行布地奈德混悬液雾化吸入治疗,观察组进行布地奈德混悬液联合吸入用硫酸沙丁胺醇溶液雾化吸入治疗。比较两组动脉血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]、肺部功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC]。结果:治疗前,两组PaO_(2)、PaCO_(2)水平比较,差异无统计学意义(P>0.05);治疗后,两组PaO_(2)水平高于治疗前,PaCO_(2)水平低于治疗前,观察组PaO_(2)水平高于对照组,PaCO_(2)水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组FEV_(1)、FVC及FEV_(1)/FVC水平比较,差异无统计学意义(P>0.05);治疗后,两组FEV_(1)、FVC及FEV_(1)/FVC水平升高,观察组高于对照组,差异有统计学意义(P<0.05)。结论:在常规治疗基础上,布地奈德混悬液联合吸入用硫酸沙丁胺醇溶液雾化吸入治疗COPD的效果较好,可改善患者血气指标及肺部通气功能。Objective:To explore the effect of budesonide combined with salbutamol nebulized inhalation in the treatment of chronic obstructive pulmonary disease(COPD)patients.Methods:Eighty COPD patients admitted to Zunyi First People's Hospital from February 2020 to December 2022 were selected as the study subjects,and were divided into the control group and the observation group by the random number table method,each with forty cases.On the basis of conventional treatment,the control group was treated with budesonide suspension nebulized inhalation therapy,and the observation group was treated with budesonide suspension combined with salbutamol sulfate solution nebulized inhalation therapy for inhalation.The arterial blood gas indexes[partial pressure of arterial oxygen(PaO_(2)),partial pressure of arterial carbon dioxide(PaCO_(2))],and lung function indexes[forced expiratory volume in the first second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC]were compared between the two groups.Results:Before treatment,there was no statistically significant difference in PaO_(2)and PaCO_(2)levels between the two groups(P>0.05);after treatment,the PaO_(2)level of the two groups was higher than that before treatment,and the PaCO_(2)level was lower than that before treatment,and the PaO_(2)level of the observation group was higher than that of the control group,and the PaCO_(2)level was lower than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,the levels of FEV_(1),FVC and FEV_(1)/FVC in the two groups were compared,and the difference was not statistically significant(P>0.05);after treatment,the levels of FEV_(1),FVC and FEV_(1)/FVC increased in the two groups,and the observation group was higher than the control group,and the difference was statistically significant(P<0.05).Conclusion:On the basis of conventional treatment,budesonide suspension combined with salbutamol sulfate solution nebulized inhalation for the treatment of COPD is more effective,which can improve the patients'

关 键 词：吸入用硫酸沙丁胺醇溶液 慢性阻塞性肺疾病 布地奈德混悬液 

分 类 号：R56[医药卫生—呼吸系统]