Targeting complement hyperactivation:a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection  

作　　者：Leili Jia Haihua Luo Lizhong Li Mingyao Wang Jiangfeng Liu Yuan Liang Shan Li Yong Jiang Juntao Yang Hongbin Song 

机构地区：[1]Institute for Disease Control and Prevention of PLA,Beijing,China [2]Guangdong Provincial Key Laboratory of Proteomics,State Key Laboratory of Organ Failure Research,School of Basic Medical Sciences,Southern Medical University,Guangzhou 510515,China [3]State Key Laboratory of Common Mechanism Research for Major Diseases,Institute of Basic Medical Sciences,Chinese Academy of Medical Science and Peking Union Medical College,100005 Beijing,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第1期51-54,共4页信号转导与靶向治疗（英文）

基　　金：supported by grants from the National Key Research and Development Program of China(Nos.2018YFC1200100,2016YFC1200905);National Key Technology R&D Program of China(No.2017ZX10104001);National Natural Science Foundation of China(Nos.30801004,81371807);NSFC-Guangdong Joint Foundation of China(No.U1601225);Beijing Municipal Natural Science Foundation(No.7122132);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-044);the National College Students Innovation and Entrepreneurship Training Program of China(No.2023zglc06011).

摘　　要：Dear Editor,Infections by the influenza virus are a significant and widespread global health threat,as these infections have an annual death toll ranging from 290,000 to 650,000.1 A significant proportion of these fatalities are attributed to secondary bacterial pneumonia,a severe complication commonly caused by ubiquitous respiratory pathogens such as Staphylococcus aureus(S.aureus).2 Of particular concern is the increased morbidity and mortality rates in individuals infected simultaneously with influenza virus and methicillin-resistant S.aureus(MRSA).3 The concurrent presence of bacteria and influenza virus usually causes acute respiratory distress syndrome(ARDS),which is associated with acute lung injury(ALI),severe lung tissue edema,and widespread inflammation.Nevertheless,determining the complex mechanisms underlying the synergistic interplay will require further investigation with a suitable coinfection mouse model.In our previous study,we utilized different sequential coinfections at various time points to model influenza A virus and MRSA coinfection.

关 键 词：INFLUENZA PNEUMONIA LUNG 

分 类 号：R563.1[医药卫生—呼吸系统]