不孕人群宫颈人乳头瘤病毒感染情况的观察性研究  

Observational study of cervical human papillomavirus infection in infertile population

作　　者：陈春艳 曾欣柳 蔡晶 刘琳[1] Chen Chunyan;Zeng Xinliu;Cai Jing;Liu Lin(Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei 430022,P.R.China)

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科,湖北武汉430022

出　　处：《中国计划生育和妇产科》2024年第1期53-57,共5页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的分析女性不孕人群人乳头瘤病毒(human papillomavirus,HPV)感染情况,探讨HPV感染和不孕症发生的相关关系。方法回顾性分析2013年1月至2022年12月于华中科技大学同济医学院附属协和医院行HPV检测的不孕症人群(不孕组)和门诊体检人群(对照组)HPV的感染情况,比较两组HPV及其不同亚型的感染情况。为了进一步明确HPV感染是否与不孕症的发生相关,使用二元Logistic回归分析探寻在不同年龄分组内和不孕症的发生相关的HPV亚型。结果两组高危型HPV及低危型HPV感染比例比较,差异均无统计学意义(P>0.05)。按不同年龄分组进行分层分析,20~30岁不孕症患者的HPV感染率低于对照组(P<0.05)。Logistic回归提示:20~30岁的年轻人群不孕症的发病与HPV感染无关。30~40岁不孕人群高危型HPV中HPV66、HPV68的感染率高于对照组,不孕症风险分别为未感染的1.396倍和1.383倍(OR:1.396,95%CI:1.083-1.800;OR:1.383,95%CI:1.054-1.816)。40~50岁不孕人群高危型HPV中HPV16、HPV66的感染率高于对照组,不孕症的风险为未感染人群的1.762倍、2.222倍(OR:1.762,95%CI:1.343-2.313;OR:2.222,95%CI:1.377-3.586)。低危型HPV中HPV6、HPV11的感染为大于30岁不孕人群不孕症发病的潜在危险因素(OR:1.463,95%CI:1.161-1.844;OR:1.935,95%CI:1.432-2.615)。结论HPV感染和女性不孕症的发病相关,HPV16、HPV66、HPV68、HPV6、HPV11亚型的感染可能为30岁以上女性不孕症的潜在危险因素。Objective Analyze the infection with the human papillomavirus(HPV)in the female infertile population,and explore the correlation between the HPV infection and the occurrence of infertility.Methods Retrospectively analyzed HPV infection in the infertile population(infertile group)and in the outpatient population(control group)who underwent HPV testing in Union Hospital,Tongji Medical College,Huazhong University of Science and Technology from January 2013 to December 2022,and compared the infection status of two groups of HPV and their different subtypes.To further clarify whether HPV infection was associated with infertility,binary Logistic regression analysis was used to explore HPV subtypes associated with infertility in different age groups.Results There was no difference in either high-risk or low-risk HPV infections between the two groups(P>0.05).Stratified analysis by age group showed that the HPV infection rate in infertility patients aged 20~30 was lower than that in the control group(P<0.05).The result of the Logistic regression suggested that the incidence of infertility in young people aged 20~30 was not related to HPV infection.The infection rates of HPV66 and HPV68 in high-risk HPV patients aged 30~40 with infertility were higher than those in the control group,and the risk of infertility was 1.396 times and 1.383 times higher than that of non infection,respectively(OR:1.396,95%CI:1.083-1.800;OR:1.383,95%CI:1.054-1.816).The infection rates of HPV16 and HPV66 in high-risk HPV patients aged 40~50 years old with infertility were higher than those in the control group.The risk of infertility was 1.762 times and 2.222 times higher than that of the uninfected population(OR:1.762,95CI:1.343-2.313;OR:2.222,95%CI:1.377-3.586).Infection with low-risk HPV subtypes HPV6 and HPV11 was a potential risk factor for the development of infertility in infertile women older than 30 years(OR:1.463,95%CI:1.161-1.844;OR:1.935,95%CI:1.432-2.615).Conclusions HPV infection is associated with the development of female infertili

关 键 词：不孕症 人乳头瘤病毒感染 HPV亚型 

分 类 号：R711.74[医药卫生—妇产科学]